Loop diuretics are used as first-line medications in patients with heart failure they result symptomatic improvement related to relieving organ congestion. The recommendations regarding the use of loop mostly based on expert opinion, without preference specific drugs. Thus, choice optimal diuretic treatment strategy acute heart requires knowledge about differences characteristics available P...

We studied the effect of furosemide on pulmonary transvascular filtration of fluid and microvascular permeability to plasma proteins by measuring steady-state lung lymph flow and protein flow, pulmonary arterial and left atrial pressures in nine 1-wk-old unanesthetized lambs before and after rapid intravenous infusion of furosemide, 1 mg/kg in 10 experiments and 8 mg/kg in 5 experiments. With r...

PURPOSE To optimize the MDCT urogram protocol for assessment of the upper tracts. To assess the value of furosemide injection. MATERIALS AND METHODS Prospective study comparing excretory phase imaging at 450 seconds in 67 patients assigned to 3 groups: a group without furosemide (f=0), a group with 20 mg furosemide (f=20), and a group with 10 mg furosemide (f=10). 3D MIP images were generated...

MEYER, PHILIPPE, JOEL MENARD, NIC~LAS PAPANICOLAOU, JEAN-M. ALEXANDRE$LAUDINE DEVAUX,AND PAUL MILLIEZ. Mechanism of renin release following furosemide diuresis in rabbit. Am. J. Physiol. 215(4) : 908-915. 1968.-Injection of furosemide (10 mg/kg, iv) into rabbits increased plasma renin activity within 7 min; plasma renin activity increased further throughout the course of the experiment and rvas...

Depression, a bewildering and burdensome illness, is one of the commonest psychiatric diseases. It is expected to be the second leading contributor to Global Disease Burden by 2020. The objective of the study was to determine the effect of nifedipine on the responses of imipramine, sertraline and furosemide in the forced swim test (FST) and tail suspension test (TST) in mice. Groups of mice wer...

The protective effects of a combination of dopamine and furosemide were studied in dogs during the initial phase of acute renal failure (ARF) induced by intravenous uranyl nitrate (10 mg/kg). Fifteen minutes after injection of the nephrotoxin, and infusion of dopamine (3 micrograms/kg/min), furosemide (1 mg/kg/bolus followed by 1 mg/kg/hr), or both drugs simultaneously were given for 6 hours. E...

The effect of furosemide on gentamicin excretion and tissue accumulation was studied with clearance techniques in anesthetized rats, at two different infusion rates of saline or Ringer solution. Gentamicin (-20 mg/kg) was administered by constant intravenous infusion over a period of 3 h. With the low fluid infusion rate, furosemide (25 mg/kg intravenously) caused severe reduction in glomerular...

Furosemide attenuates hyperpnea-induced airway obstruction (HIAO) in asthmatic subjects via unknown mechanism(s). We studied the effect of furosemide on dry air-induced bronchoconstriction, mucosal injury, and bronchovascular hyperpermeability in a canine model of exercise-induced asthma. Peripheral airway resistance (Rp) was recorded before and after a 2-min dry-air challenge (DAC) at 2,000 ml...

Cochlear trauma causes increased spontaneous activity (hyperactivity) to develop in central auditory structures, and this has been suggested as a neural substrate for tinnitus. Using a guinea pig model we have previously demonstrated that for some time after cochlear trauma, central hyperactivity is dependent on peripheral afferent drive and only later becomes generated intrinsically within cen...

The objective of the current study was to develop and validate a simple, precise and accurate isocratic stability-indicating reversed-phase high-performance liquid chromatography (RP-HPLC) assay method for the determination of spironolactone and furosemide in solid pharmaceutical dosage forms. Isocratic RP-HPLC separation was achieved on an SGE 150 × 4.6 mm SS Wakosil II 5C8RS 5-μm column using...