Vaults are barrel-shaped cytoplasmic ribonucleoprotein particles that are composed of a major vault protein (MVP), two minor vault proteins [telomerase-associated protein 1 (TEP1), vault poly(ADP-ribose) polymerase (VPARP)] and small untranslated RNA molecules. Not all expressed TEP1 and VPARP in cells is bound to vaults. TEP1 is known to associate with the telomerase complex, whereas VPARP is ...

This paper describes the design and implementationof an on-line, distributed data repository, known as an electronic vault (e-Vault), which stores information across a network securely so that integrity is preserved even when some of the servers malfunction. After a document has been deposited by a client, the e-Vault returns a receipt to the client which can be used to verify that the document...

Vaults and telomerase are ribonucleoprotein (RNP) particles that share a common protein subunit, TEP1. Although its role in either complex has not yet been defined, TEP1 has been shown to interact with the mouse telomerase RNA and with several of the human vault RNAs in a yeast three-hybrid assay. An mTep1(-/-) mouse was previously generated which resulted in no apparent change in telomere leng...

OBJECTIVE To evaluate morphology and frequency of lower genital infections in (post hysterectomy) vault smears of women. METHODS We analyzed vault smears from 500 women who had undergone hysterectomy, either for benign diseases (230) or for carcinoma cervix (270) and findings were compared with Pap smear diagnosis of non-hysterectomy subjects. RESULTS Majority 432/500 (87%) of the vault sme...

Vault is the largest nonicosahedral cytosolic nucleoprotein particle ever described. The widespread presence and evolutionary conservation of vaults suggest important biologic roles, although their functions have not been fully elucidated. X-ray structure of vault from rat liver was determined at 3.5 Å resolution. It exhibits an ovoid shape with a size of 40 × 40 × 67 nm(3). The cage structure ...

The fuzzy commitment scheme is a cryptographic primitive that can be used to protect biometric templates. If multiple records extracted from the same biometric characteristic have been intercepted, their correspondence can be examined, i.e., cross-matching, via the decodability attack. As a countermeasure, Kelkboom et al. proposed to apply a public but record-specific permutation to the feature...

Multibiometric Systems: Fusion Strategies and Template Security By Karthik Nandakumar Multibiometric systems, which consolidate information from multiple biometric sources, are gaining popularity because they are able to overcome limitations such as non-universality, noisy sensor data, large intra-user variations and susceptibility to spoof attacks that are commonly encountered in unibiometric ...

A 104-kD protein was coimmunoprecipitated with the estrogen receptor from the flowtrough of a phosphocellulose chromatography of MCF-7 cell nuclear extract. mAbs to this protein identified several cDNA clones coding for the human 104-kD major vault protein. Vaults are large ribonucleoprotein particles of unknown function present in all eukaryotic cells. They have a complex morphology, including...

The vault complex is a ubiquitous 13-MDa ribonucleoprotein assembly, composed of three proteins (TEP1, 240 kDa; VPARP, 193 kDa; and MVP, 100 kDa) that are highly conserved in eukaryotes and an untranslated RNA (vRNA). The vault has been shown to affect multidrug resistance in cancer cells, and one particular component, MVP, is thought to play a role in the transport of drug from the nucleus. To...

OBJECTIVE This article presents and discusses a new surgical abdominal technique for the treatment of posthysterectomy vaginal vault prolapse. METHOD It provides support of the peritoneal surface of the pelvic floor by means of a Gore-Tex mesh, which closes this space. The vaginal vault is fixed to the centre of the mesh. STUDY DESIGN Descriptive study. RESULTS Sixteen patients with vagin...