El cumplimento de las Guías Alimentarias Basadas en Alimentos (GABA) vigentes Chile, asegura una alimentación suficiente y equilibrada. Objetivo: Determinar el cumplimiento 5 recomendaciones GABA su asociación con variables antropométricas, estilo vida metabólicas, adolescentes que participaron la Encuesta Nacional Salud 2016-2017. Sujetos Método: Estudio transversal incluyó 355 entre 15 a 19 a...

Background: It has been suggested that organophosphates may inhibit gamma-aminobutyric acid (GABA) metabolism in synaptosomal preparations. In the present investigation, we have assessed the interaction between paraoxon and the GABA system at synaptic level. Methods: Synaptosomes were prepared from male Wistar rats (200-250 g). Cerebral cortex was dissected and homogenized, then centrifuged at ...

A small library of anilino enaminones was analyzed for potential anticonvulsant agents. We examined the effects of three anilino enaminones on neuronal activity of output neurons, mitral cells (MC), in an olfactory bulb brain slice preparation using whole-cell patch-clamp recording. These compounds are known to be effective in attenuating pentylenetetrazol-induced convulsions. Among the three c...

Antigen-based therapies (ABTs) very effectively prevent the development of type 1 diabetes (T1D) when given to young nonobese diabetic (NOD) mice, however, they have little or no ability to reverse hyperglycemia in newly diabetic NOD mice. More importantly, ABTs have not yet demonstrated an ability to effectively preserve residual ß-cells in individuals newly diagnosed with type 1 diabetes (T1D...

Metabotropic GABA(B) receptors are abundantly expressed at glutamatergic synapses where they control excitability of the synapse. Here we tested the hypothesis that glutamatergic neurotransmission may feed back to regulate GABA(B) receptors. We found that application of glutamate to cultured cortical neurons led to rapid downregulation of GABA(B) receptors via lysosomal degradation. This effect...

82 | 2010 | VOLUME 1 VANDERBILT REVIEWS | NEUROSCIENCE ©2010 Vanderbilt Brain Institute. All rights reserved. GLUTAMATE AND GABA METABOLISM Glutamate and GABA are the major excitatory and inhibitory neurotransmitters in the brain, respectively. Unlike other neurotransmitter systems, such as monoamines, reuptake and recycling of glutamate and GABA does not appear to be as important as new synthe...

The effect of prolactin on the activity of GABA-related enzymes and GABA concentrations were studied in hypothalamic slices incubated in vitro. After short periods of incubation (up to 40 min), prolactin (0.25 micrograms/ml) added to the incubation medium produced a significant increase (21% at 20 min of incubation) in glutamic acid decarboxylase (GAD) activity in the hypothalamic slices. A hig...