نتایج جستجو برای: gabaa

تعداد نتایج: 5354  

Journal: :Journal of neurophysiology 2004
Alexander O Komendantov Olena G Komendantova Steven W Johnson Carmen C Canavier

Midbrain dopaminergic (DA) neurons in vivo exhibit two major firing patterns: single-spike firing and burst firing. The firing pattern expressed is dependent on both the intrinsic properties of the neurons and their excitatory and inhibitory synaptic inputs. Experimental data suggest that the activation of N-methyl-D-aspartate (NMDA) and GABAA receptors is a crucial contributor to the initiatio...

Journal: :Anesthesiology 2007
Christian Grasshoff Berthold Drexler Harald Hentschke Horst Thiermann Bernd Antkowiak

BACKGROUND Victims of organophosphate intoxication with cholinergic crisis may have need for sedation and anesthesia, but little is known about how anesthetics work in these patients. Recent studies suggest that cholinergic stimulation impairs gamma-aminobutyric acid type A (GABAA) receptor function. Because GABAA receptors are major targets of general anesthetics, the authors investigated inte...

Journal: :Frontiers in cellular neuroscience 2016
Diana Elinos Raúl Rodríguez Luis Andres Martínez María Elena Zetina Fredy Cifuentes Miguel Angel Morales

Sympathetic neurons have the capability to segregate their neurotransmitters (NTs) and co-transmitters to separate varicosities of single axons; furthermore, in culture, these neurons can even segregate classical transmitters. In vivo sympathetic neurons employ acetylcholine (ACh) and other classical NTs such as gamma aminobutyric acid (GABA). Herein, we explore whether these neurons in vivo se...

علاءالدینی, آرش, علی پور, فاطمه, مدرس موسوی, مصطفی, هاشمی, زهراسادات,

مقدمه: نورون‏‌های ترشح کنندۀ گاما آمینو بوتریک اسید که یک ناقل عصبی مهاری است و به‏ عنوان ناقل عصبی اصلی شناخته می‏‌شود، نورون‏‌های گابائرژیک نامیده می‏‌شوند. فیلوژنتیک بر اساس اطلاعات ترتیبی، توصیف دقیق‏‌تری از الگوهای وابستگی را فراهم می‏‌نماید. مواد و روش‌ها: پس از هم‌ردیفی توالی‌های کامل ژن mRNA زیرواحدهای آلفای GABAA در گونه‌های انسان و موش صحرایی، درخت فیلوژنتیک با نرم‌افزار CLC Main Work...

Journal: :Vision Research 1998
Ralf Enz Garry R Cutting

In the central nervous system inhibitory neurotransmission is primarily achieved through activation of receptors for gamma-aminobutyric acid (GABA). Three types of GABA receptors have been identified on the basis of their pharmacology and electrophysiology. The predominant type, termed GABAA and a recently identified type, GABAC, have integral chloride channels, whereas GABAB receptors couple t...

2016
Soledad Domínguez David Fernández de Sevilla Washington Buño

Acetylcholine (ACh) regulates network operation in the hippocampus by controlling excitation and inhibition in rat CA1 pyramidal neurons (PCs), the latter through gamma-aminobutyric acid type-A receptors (GABA A Rs). Although, the enhancing effects of ACh on GABA A Rs have been reported (Dominguez et al., 2014, 2015), its role in regulating tonic GABAA inhibition has not been explored in depth....

1997
G. SPERK

–The GABAA receptor is a ligand-operated chloride channel. It has a pentameric structure. In mammalian brain different subunits are recruited from four gene subfamilies. Using immunocytochemistry, we investigated the distribution of the 13 GABAA receptor subunits in the hippocampus of the rat. GABAA receptor subunits were heterogeneously distributed within different hippocampal subfields. High ...

2014
Yang Xia Yuan Zhao Mingpo Yang Shaoqun Zeng Yousheng Shu

GABAA receptors distributed in somatodendritic compartments play critical roles in regulating neuronal activities, including spike timing and firing pattern; however, the properties and functions of GABAA receptors at the axon are still poorly understood. By recording from the cut end (bleb) of the main axon trunk of layer -5 pyramidal neurons in prefrontal cortical slices, we found that curren...

2014
Artur Kessler Hilal Sahin-Nadeem Sarah C R Lummis Ingrid Weigel Monika Pischetsrieder Andrea Buettner Carmen Villmann

SCOPE GABAA receptors are modulated by Sideritis extracts. The aim of this study was to identify single substances from Sideritis extracts responsible for GABAA receptor modulation. METHODS AND RESULTS Single volatile substances identified by GC have been tested in two expression systems, Xenopus oocytes and human embryonic kidney cells. Some of these substances, especially carvacrol, were hi...

Journal: :The Journal of biological chemistry 2003
Yong Li Long-Jun Wu Pascal Legendre Tian-Le Xu

Presynaptic nerve terminals of inhibitory synapses in the dorsal horn of the spinal cord and brain stem can release both GABA and glycine, leading to coactivation of postsynaptic GABAA and glycine receptors. In the present study we have analyzed functional interactions between GABAA and glycine receptors in acutely dissociated neurons from rat sacral dorsal commissural nucleus. Although the app...

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