نتایج جستجو برای: gabaar
تعداد نتایج: 322 فیلتر نتایج به سال:
28 GABA is the major inhibitory neurotransmitter in the central auditory system. Sensory 29 thalamic structures show high levels of non-desensitizing extrasynaptic GABAA receptors 30 (GABAARs) and a reduction in the redundancy of coded information. The present study 31 compared the inhibitory potency of GABA acting at GABAARs between the inferior 32 colliculus (IC) and the medial geniculate bod...
-Aminobutyric acid (GABA) binding to GABAA receptors (GABAARs) triggers conformational movements in the 1 and 2 pre-M1 regions that are associated with channel gating. At high concentrations, the barbiturate pentobarbital opens GABAAR channels with similar conductances as GABA, suggesting that their open state structures are alike. Little, however, is known about the structural rearrangements i...
The female epilepsy protein PCDH19 is a new GABAAR-binding partner that regulates GABAergic transmission as well as migration and morphological maturation of hippocampal neurons S. Bassani, A.W. Cwetsch, L. Gerosa, G.M. Serratto, A. Folci, I.F. Hall, M. Mazzanti, L. Cancedda, and M. Passafaro . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....
Basal ganglia play an essential role in motor coordination and cognitive functions. The GABAergic medium spiny neurons (MSNs) account for ~95% of all the neurons in this brain region. Central to the normal functioning of MSNs is integration of synaptic activity arriving from the glutamatergic corticostriatal and thalamostriatal afferents, with synaptic inhibition mediated by local interneurons ...
22 Dopaminergic neurons are subject to a significant background GABAergic input 23 in vivo. The presence of this GABAergic background might be expected to inhibit 24 dopaminergic neuron firing. However, dopaminergic neurons are not all silent but instead 25 fire in single-spiking and burst firing modes. Here we present evidence that phasic 26 changes in the tonic activity of GABAergic afferents...
In the present study, we have elucidated the functional characteristics and mechanism of action of methaqualone (2-methyl-3-o-tolyl-4(3H)-quinazolinone, Quaalude), an infamous sedative-hypnotic and recreational drug from the 1960s-1970s. Methaqualone was demonstrated to be a positive allosteric modulator at human α1,2,3,5β2,3γ2S GABAA receptors (GABAARs) expressed in Xenopus oocytes, whereas it...
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