Triterpenes isolated from Ganoderma lucidum could inhibit the growth of numerous cancer cell lines and were thought to be the basis of the anticancer effects of G. lucidum. Ganoderic acid D (GAD) is one of the major components in Ganoderma triterpenes. GAD treatment for 48 h inhibited the proliferation of HeLa human cervical carcinoma cells with an IC(50) value of 17.3 +/- 0.3 microM. Flow cyto...

Preliminary evidence supports the role of emotion-related deficits in generalized anxiety disorder (GAD), including heightened emotional intensity, poor understanding of emotion, negative cognitive reactivity to emotions, and maladaptive emotion management. However, questions remain concerning the specificity of these emotion-related deficits compared to highly comorbid conditions such as socia...

Generalized anxiety disorder (GAD) is one of the most common psychiatric disorders encountered in the primary care setting. Lifetime prevalence of GAD is approximately 5% in the U.S. adult population [1,2]; prevalence in the primary care setting has been estimated at 8% [3,4]. GAD usually has a chronic course that is associated with significant psychosocial impairment, disability, decreased qua...

Of the pervasive anxiety disorders diagnosed in late life, generalized anxiety disorder (GAD) is the most prevalent. However GAD often goes unrecognised and untreated because of different clinical presentation in the elderly. Anxiety is also substantially less well studied than other forms of geriatric psychopathology. This dearth of research may result from methodological difficulties. In this...

BACKGROUND Cognitive function in anxiety disorders has been the subject of limited investigation, especially in generalized anxiety disorder (GAD). The purpose of this study was to investigate the cognitive function in subjects with GAD using mismatch-triggered negativity N270. METHODS Fifteen medication-free patients with a DSM-IV diagnosis of GAD, and 15 well-matched healthy controls perfor...

AIM To psychometrically validate the Spanish version of the self-administered 2-item GAD-2 scale for screening probable patients with generalised anxiety disorder (GAD). METHODS The GAD-2 was self-administered by patients diagnosed with GAD according to DSM-IV criteria and by age- and sex-matched controls who were recruited at random in mental health and primary care centres. Criteria validit...

Emerging evidence suggests significant influence of comorbid anxiety on COPD. Several studies have reported a high prevalence of anxiety in COPD, but the rates vary widely. Review articles have reported the prevalence of GAD is 10% 15.8% in COPD patients compared to 3.6% 5.1% in the general public. We aim to study the prevalence of GAD in COPD patients and general population. Patients of COPD w...

The goal of the current work is to provide a comprehensive review and interpretation of the literature on the human and economic burden of generalized anxiety disorder (GAD) and how it compares with that of other mental disorders. The term "human burden" is used to describe quantified impairments in role functioning and quality of life (QOL). "Economic burden" describes costs related to health ...

objective: acceptance-based behavior therapy (abbt) is a new psychotherapy for generalized anxiety disorder (gad). the current study intended to compare severity of symptoms, worry and quality of life of gad female patients between abbt and control. methods: this study was a randomized clinical trial. the sample included 18 women with gad referred to psychiatrists in isfahan, iran. patients wer...

This study examined transdiagnostic features of generalized anxiety disorder (GAD) and dysthymia in an outpatient clinical sample. Fifteen patients who met DSM-IV criteria for GAD and twenty-one patients who met DSM-IV criteria for dysthymia but who did not have comorbid anxiety disorder were evaluated utilizing the Rorschach. Salient clinical variables were then compared. Results showed that p...