During these last years, cyclodextrins have contributed greatly to the development of catalytic processes in water. These cyclic oligosaccharides composed of 6(), 7() or 8() glucopyranose units improve the mass transfer in aqueous-organic two-phase systems and are useful compounds to design new catalysts. Thus, chemically modified cyclodextrins can be used to: (i) increase significantly the ...

A multidentate ligand is bonded to cyclodextrins by the reaction of diethylenetriaminepentaacetic dianhydride with 6-monoand 2-mono(ethylenediamine) derivatives of cyclodextrin. Adding Dy(II1) to the cyclodextrin derivatives enhances the enantiomeric resolution in the IH N M R spectra of carbinoxamine maleate, doxylamine succinate, pheniramine maleate, propranolol hydrochloride, and tryptophan....

Cyclodextrins are molecules with a hollow, truncated cone shape that possess unique lipophilic and hydrophilic properties. These unique properties enable cyclodextrins to engulf and bind lipophilic molecules while maintaining aqueous solubility. Encapsulation of molecules is the principal action of a new drug class, selective relaxant binding agents, which binds and inactivate aminosteroid nond...

An inclusion complex consisting of a fluorescent phenylboronic acid (C1-APB) and beta-cyclodextrin (beta-CD) acts as a supramolecular saccharide sensor whose response mechanism is based on photoinduced electron transfer (PET). This study evaluated four kinds of cyclodextrins (alpha-CD, beta-CD, gamma-CD, and NH(2)-beta-CD) by comparing their pH profiles, and confirmed that beta-CD was the best ...

Enzymatic protein hydrolysates of milk are used as a component functional foods intended for children, athletes, and senior citizens. They easy to absorb possess hypoallergenic, antioxidant, antimicrobial, antimutagenic properties. However, the peptides in their composition have bitter taste, which limits use food industry. Functional often fortified with fat-soluble vitamins other hydrophobic ...

In the present investigation mefenamic acid prodrug of ß-cyclodextrins was synthesized. The primary hydroxy group of ß-cyclodextrins was used to block the acid group. The synthesis involved a series of protection and deprotection reaction. The ester was evaluated for stability in simulated gastric and intestinal fluid. The hydrolysis of cyclodextrin conjugate in colon is confirmed by the hydrol...

Reaction at the interface of an organic solution containing an acidic reactant and an aqueous alkaline solution containing nonreducing carbohydrates such as sucrose, sugar alcohols, cyclodextrins, and polysaccharides imparts a specificity to the reaction for one or more of the primary alcohol groups of the carbohydrate reactant. The resulting activated, nonreducing carbohydrate intermediate can...

Beta-lapachone (beta-lap) is a novel anticancer agent that kills tumors overexpressing the NADPH: quinone oxidoreductase enzyme. However, poor aqueous solubility and low bioavailability hinder its therapeutic applications. Herein we describe the development of poly(D,L-lactide-co-glycolide) (PLGA) polymer millirods for local delivery of beta-lap. The objective was to investigate the use of beta...