Gamma-irradiation is finding increasing use in the sterilization of pharmaceutical products. However, irradiation might also affect the performance of drug delivery systems. In this study, the influence of gamma-irradiation on the physicochemical properties of two commonly used non-steroidal anti-inflammatory drugs (NSAIDs) [naproxen sodium (NS) and diclofenac sodium (DS)] was investigated. The...

Oxidative degradation of ultra-high molecular weight polyethylene (UHMWPE; PE), due to gamma irradiation sterilization in air, increases wear rate in artificial joint. Not only adhesive and abrasive wear but also delamination (flaking), a typical wear of the PE component in artificial knee joint, and fracture could be observed. This paper deals with gamma-irradiation effects on severe wear mech...

The food packaging industries have got a problem of deterioration of sterilized food due to the attack of micro organism. This is due to the re-contamination of the food during packaging process. The recontamination after packaging can be avoided by sterilizing the packed foods. This will help to increase the shelf life of the food by killing the micro organism. Sterilization of the packed food...

OBJECTIVE: To determine the optimal radiation dose and observe the influence of radiation sterilization on spirulina polypeptide powder. METHODS: The polypeptide powder of spirulina was sterilized using a 60Coγ ray. RESULTS: Radiation sterilization had significant effects on spirulina polypeptide powder, which was more effective with increasing radiation dose. Taking the sterilization rate and ...

On September 2, 1982, a 64-year-old man accidently received a heavy dose of gamma radiation in a plant for sterilization by radiation. He developed an acute radiation syndrome. The leukocyte count rapidly diminished to low values, and extensive chromosome injuries could be demonstrated in cultured lymphocytes. He was hospitalized in an isolated room, and received large doses of antibiotics, and...

Rats with retrograde proteus pyelonephritis were treated with antibiotics until their kidneys became sterile. Using fluorescent antibody techniques, specific P. mirabilis antigen was found in some sterile pyelonephritic kidneys 20 weeks after cessation of treatment and presumed renal sterilization. Persistent antigen was associated with interstitial chronic inflammation but not with acute infla...