Diallyl trisulfide (DATS) is one of the major constituents in garlic oil and has been documented to transcriptionally activate phase II enzymes. The purpose of this study is to evaluate the effects of DATS in prolonging disease duration and survival in a transgenic mouse model of amyotrophic lateral sclerosis (ALS). SOD1-G93A transgenic mice were randomly divided into DATS-treated group (80mg/k...

Background: Oral garlic supplementation may be effective in decreasing serum cholesterol levels as much as 15% to 20%. Garlic indirectly effect atherosclerosis by reduction of hyperlipidemia, hypertension and probably diabetes mellitus and prevents thrombus formation. This study was undertaken to test the hypothesis that garlic powder with a prolonged mode of action promises potent biological e...

BACKGROUND The objective of this study was to compare between the clinical and radiographic effects of Allium sativum oil and those of formocresol in vital pulpotomy in primary teeth. MATERIALS AND METHODS A total of 20 children age ranged from 4 to 8 years were included in the study. In every one of those children, the primary molars indicated for pulpotomy. Pulpotomy procedure was performed...

Skin cancer is a serious concern whose incidence is increasing at an alarming rate. Allyl sulfides-i.e., sulfur metabolites in garlic oil-have been demonstrated to have anticancer activity against several cancer types, although the mechanisms underlying these effects remain enigmatic. Our previous study showed that diallyl trisulfide (DATS) is more potent than mono- and disulfides against skin ...

TRPA1 is an excitatory ion channel targeted by pungent irritants from mustard and garlic. TRPA1 has been proposed to function in diverse sensory processes, including thermal (cold) nociception, hearing, and inflammatory pain. Using TRPA1-deficient mice, we now show that this channel is the sole target through which mustard oil and garlic activate primary afferent nociceptors to produce inflamma...

OBJECTIVE Garlic (Allium sativum) has been suggested to affect several cardiovascular risk factors. Its antiatherosclerotic properties are mainly attributed to allicin that is produced upon crushing of the garlic clove. Most previous studies used various garlic preparations in which allicin levels were not well defined. In the present study, we evaluated the effects of pure allicin on atherogen...

Garlic preparations and propranolol (PRO) are agents recognized as cardioprotective and potent antihypertensive agents when they are used individually. However, there is no report available to explain the role of combined therapy during simultaneous hypertension and myocardial damage in rats. We aimed to determine the pharmacokinetic and pharmacodynamic interaction of PRO with garlic homogenate...

It is imperative to emphasize the wear-reducing and load-sustaining abilities of lubricating oils, as they are an essential part their operation. In this study, anti-wear extreme pressure (EP) performance Jatropha oil was explored. The investigation executed on a 4-ball tester machine according ASTM-D-4172 D-2783 standards. Nano-sized Molybdenum disulfide graphene were added base oil, whose add...

Feeding of 2% cholesterol diet increased lipid parameters in serum and tissues of rats during a period of one month. In addition to the above, lipid peroxidation also increased and activities of certain enzymes were significantly altered in the tissues. Similar changes were also observed to a greater extent with diets containing 40% by weight of coconut kernel or groundnut with and without 2% c...

Microorganisms are ubiquitous in every habitat on earth. Some can be pathogenic and the need for controlling them is a topic of immense research. Tea tree oil (Melaleuca alternifolia) is known to have antibacterial effects and in this experiment we tested its abilities to control the growth of five bacteria Bacillus subtilis, Escherichia coli, Micrococcus roseus, Sarcina luteus, and Serratia ma...