Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme degradation, is an integral membrane protein of the smooth endoplasmic reticulum. However, we detected an HO-1 immunoreactive signal in the nucleus of cultured cells after exposure to hypoxia and heme or heme/hemopexin. Under these conditions, a faster migrating HO-1 immunoreactive band was enriched in nuclear extracts, suggesting that H...

Sialic acids have been found to mask antigens, receptors and other recognition sites on molecules and cells. This has been investigated best with hepatocyte and macrophage lectins which recognize 13-galactose and N-acetyl-13-galactosamine residues on molecules and cells exposed by sialidase treatment. The lectin on macrophages leads to the binding and phagocytosis of erythrocytes after the enzy...

Background:Extraction of drugs is one of the biggest concerns and the most important part of preparation and determination in forensic medicine. The lack of an easy, efficient and fast extraction method is the most important and most difficult problem despite the development of forensic centers and their being equipped with new diagnostic devices. In the present study, a comparison was conducte...

The influence of ocean–atmosphere interaction on the wintertime Arctic oscillation (AO) is investigated using a hierarchy of experiments made with two general circulation models (GCMs), ranging from climatologically forced atmospheric to fully coupled ocean–atmosphere GCMs with increasing greenhouse gas concentrations. Both GCMs reproduce well the AO spatial pattern, defined by the leading hemi...

Explanted polypropylene (PP) surgical mesh has frequently been reported to show surface alterations, such as cracks and flaking. However, date the consequence of PP degradation is not clearly understood, particularly its potential influence biological host response surrounding tissues. Of particular concern a possible reaction particles released through in vivo. This driven by previous studies ...

A validated method for the quantitative determination of venlafaxine, O-desmethylvenlafaxine in human plasma by tandem liquid chromatographymass spectrometry (HPLC/MS/MS) has been proposed. Sample preparation was carried out liquid-phase extraction with support (SLE, from «supported extraction») using HyperSEP cartridges and washing 3-methylbutyl ether. The measure target analytes on a triple q...

Human soft tissue specimens obtained by dissection of Greco-Roman Period mummies buried in the Dakhleh Oasis in Egypt's Western Desert had radiocarbon analytical results many of which were substantially older than accompanying artifacts suggested. Mass spectrometry suggested the presence of hydrocarbons. Gas chromatography/mass spectrometry (GCMS) confirmed that the “resin” applied to these bod...

We are now launching the first issue of the first volume of the International Journal of Analytical Mass Spectrometry and Chromatography (IJAMSC). This newly launched journal is an open access journal, whose primary aim is to provide a platform for researchers and practitioners, worldwide, to promote, share, and discuss various new issues and developments in all areas of Mass Spectrometry and C...