background: it is not yet known which types of toll-like receptors (tlrs) are most effective in helicobacter pylori (h. pylori) recognition. it is also not known which gastric zones have the most prominent roles in tlr-mediated bacterial recognition. the aim of this work was to analyze the expression of tlr2 and tlr4 in biopsy specimens from h. pylori-infected patients. methods: thirty-eight pa...

introduction: mental stress is one of the most important causes of the gastric ulcer. on the other hand, flavonoids such as quercetin show protective effects. the aim of this study was to investigate possible protective effect of quercetin on water restraint stress-induced ulcer in rats. methods: adult male wistar rats were divided into seven groups each containing eight animals. the first grou...

Although colonization with any Helicobacter pylori strain is associated with peptic ulcer, it is uncertain whether the risk is greater with cagA(+) or cagA(-) strains, which differ in their biology. A nested case-control study was done, based on a cohort of 5,443 Japanese-American men examined on the Hawaiian island of Oahu from 1967 to 1970. A total of 150 men with gastric ulcer, 65 with duode...

1. Gastric juice was obtained during continuous maximal stimulation with histamine diphosphate, 0.13 pmol h-' kg-l (0.04 mg h-' kg-l) intravenously, in thirtyfour control subjects, twenty-eight patients with duodenal ulcer, and eighteen with gastric ulcer. After correction for pyloric losses, the average rate of outputs of water, and of H', Na', K+ and C1were determined. 2. The results were ana...

Basal and pentagastrin stimulated gastric secretion was measured in seven patients with duodenal, and six with gastric ulcers before and after four weeks' treatment with colloidal bismuth subcitrate (as De-Nol), one tablet four times a day. Each duodenal and all but one of the gastric ulcers healed. After De-Nol there were no significant changes in basal, or pentagastrin stimulated volume, acid...

Activated platelets are involved in cancer development and progression. Mean platelet volume (MPV) and platelet distribution width (PDW) are early indexes of platelet activation. The objectives of this study were to investigate the ability of MPV, PDW and carcinoembryonic antigen (CEA) individually or in combination, to distinguish between gastric cancer and gastric ulcer. The study involved 19...

INTRODUCTION Helicobacter pylori (H. pylori) occurs throughout the world and causes gastroduodenal diseases. There is data indicating a change in the prevalence of H. pylori infection worldwide. The prevalence of H. pylori is 80% in Turkey, while it is higher in many developing countries, and the rate of infection varies throughout the world. In many developing countries, the prevalence of infe...

The susceptibility of healed, experimental gastric ulcers to chemical carcinogenesis was investigated. Slowly healing gastric ulcers were induced by the acetic acid method in the fundic and pyloric gastric mucosae of inbred male Wistar rats. N-Methyl-N'-nitro-N-nitrosoguanidine (MNNG) was administered in drinking water at a concentration of 50 mg/liter for 360 days after ulcer induction. Twenty...

In a series of 68 patients with gastric ulcer who were treated by vagotomy and pyloroplasty there were no operative deaths, though one patient who received massive transfusions died 14 weeks later from hepatic necrosis probably associated with serum hepatitis. Four patients developed recurrent peptic ulceration requiring further surgical treatment. The clinical condition of all but three of the...

In Central Europe and in South Africa duodenal ulcer disease has been reported to occur twice as often in migrant workers as in the indigenous population. To investigate the reasons for this phenomenon the joint effect of occupation and nationality on the prevalence of gastric and duodenal ulcer was studied in a survey of 73,000 active members of the German workforce. Non-ulcer dyspepsia and ga...