The clinical presentation of noncystic fibrosis bronchiectasis may be complicated by concomitant conditions, including gastro-oesophageal reflux (GOR). Increased acidic GOR is principally caused by gastro-oesophageal junction incompetence and may arise from lower oesophageal sphincter hypotension, including transient relaxations, hiatus hernia, and oesophageal dysmotility. Specific pathophysiol...

The oral route is the best and most popular for administration of drugs in systemic circulation. There are number which given through route. Gastro-retentive drug delivery system very important system. gastro-retentive prolonged time git also improve their bioavailability. These widely used site specific treatment disorders diseases. approaches gastro retentive such as floating system, mucoadhe...

Observations on the effect of smoking on lower oesophageal sphincter pressure (LOSP) are based on station pull-through techniques of eosophageal manometry and recent studies have suggested that these techniques are inaccurate. Reproducible measurements of LOSP may be achieved with a rapid pull-through (RPT) method of manometry. This method was used to determine the effect of cigarette smoking o...

Exopolysaccharides are high molecular weight polymers of repeated sugar units with diverse chemical structure and unique properties produced by microorganisms. Lactic acid bacteria important exopolysaccharide producers. derived exopolysaccharides, one the postbiotics, known to have technological such as stabilizing, thickening, emulsifing also biological activities. can synthesis exopolysacchar...

Obervations on the effect of smoking on lower oesophageal sphincter pressure (LOSP) are based on station pull-through techniques of oesophageal manometry and recent studies have suggested that these techniques are inaccurate. Reproducible measurements of LOSP may be achieved with a rapid pull-through (RPT) method ofmanometry. This method was used to determine the effect of cigarette smoking on ...

BACKGROUND Traditional non-steroidal anti-inflammatory drugs (NSAIDs) are a widely used class of therapy in the treatment of chronic pain and inflammation. The drugs are effective and can be relatively inexpensive thanks to available generic versions. Unfortunately the traditional NSAIDs are associated with gastrointestinal complications in a small proportion of patients, requiring costly co-th...

We studied the effect of cisapride on oesophageal motor function and postprandial gastro-oesophageal reflux in a randomised, double blind, placebo controlled crossover study. In 16 patients with symptomatic gastro-oesophageal reflux, cisapride 10 mg orally and placebo were studied on separate days according to identical protocols. Cisapride and placebo were given 30 minutes before a standard me...

Participants Les sociétés savantes et associations professionnelles suivantes ont été sollicitées pour l’élaboration de ces recommandations : Association française pour l’étude du foie ; Club de réflexion des cabinets et groupes d’hépato-gastroentérologue ; Collège national des généralistes enseignants ; Groupe francophone d’hépatologie gastro-entérologie et nutrition pédiatriques ; Société fra...

The protective and lubricative r6le of mucus in the gastro-intestinal tract has been reported and studied by many investigators (Claude Bernard (4), Schiff (18), de Klug (12), Whitlow (19), Elliott (7), Pavlov (16), Berg and Jobling (3), Leriche (14), and Bucher (6)). An absolute or relative deficiency of gastric mucus has been frequently suggested as a possible etiologic factor in gastro-duode...

conclusions a significant number of patients would benefit from surgical therapy to treat their gerd symptoms, but some incorrect beliefs still misguide the indications for the surgical procedure. results our review showed that: (a) the mortality rate of the surgical procedure is negligible and ppi therapy is also accompanied with mortality; (b) there is a 5% chance of severe dysphagia after an...