IMPORTANCE Burden of disease should inform research prioritization. OBJECTIVE To determine whether systematic reviews and protocols published in the Cochrane Database of Systematic Reviews (CDSR) appropriately reflect disease burden for otolaryngologic conditions as measured by the Global Burden of Disease (GBD) 2010 project. DESIGN Two investigators independently assessed 10 otolaryngologi...

Multiband coherent communication is being handled as a promising candidate to address the increasing demand for higher data rates and capacity. At same time, expected enter center domain in near future. With links both, data- telecom, spanning multiple optical bands, novel approaches transceiver design traffic engineering will become necessity. In this work, we present monolithically integrated...

1450 www.thelancet.com Vol 388 October 8, 2016 The Global Burden of Disease Study 2015 (GBD 2015) is a landmark event. Building on the earlier GBD studies it provides a detailed snapshot of the state of global health and an analytic approach to tracking this dynamic picture. As the international community embarks on the transition from the Millennium Development Goals (MDGs) to the Sustainable ...

Multi-eigenvalues transmission with information encoded simultaneously in both orthogonal polarizations is experimentally demonstrated. Performance below the HD-FEC limit is demonstrated for 8-bits/symbol 1-GBd signals after transmission up to 207 km of SSMF.

Three studies examined the relationship between social dominance orientation (SDO), the experience of moral elevation, and Whites' donations to charitable organizations. Study 1 used video clips depicting acts of moral excellence to elicit a state of moral elevation (a distinctive feeling of warmth and expansion, which is accompanied by admiration, affection, and even love for people whose exem...

In the Global Burden of Disease (GBD) project the question has been raised whether disability-adjusted life years (DALYs) should measure average health only, or also capture concerns for fairness and equity. The following is a brief comment on this issue. I first distinguish between goodness in health care in terms of objective health gain, individual utility, and societal value. I then show th...

This work investigates the computational procedures used to obtain global solution to the Economic Linear Optimal Control (ELOC) problem. The proposed method employs the Generalized Benders Decomposition (GBD) algorithm. Compared to the previous branch and bound approach, a naive application GBD to the ELOC problem will improve computational performance, due to less frequent calls to computatio...

Following the 1990 Global Burden of Disease (GBD) study, Disability-Adjusted Life Years (DALYs) have been used widely to quantify the population health burden of diseases and to prioritise and evaluate the impact of specific public health interventions. In the context of the recent release of the 2010 GBD study, we explore the novel use of DALYS to determine health-based targets (HBTs). As with...

RLIP76 is an effector for Ral small GTPases, which in turn lie downstream of the master regulator Ras. Evidence is growing that Ral and RLIP76 play a role in tumorigenesis, invasion, and metastasis. RLIP76 contains both a RhoGAP domain and a Ral binding domain (GBD) and is, therefore, a node between Ras and Rho family signaling. The structure of the RhoGAP-GBD dyad reveals that the RLIP76 RhoGA...