نتایج جستجو برای: gdc composite
تعداد نتایج: 122413 فیلتر نتایج به سال:
BACKGROUND Children cared for by a child minder (CM) should be less exposed to upper respiratory tract infections than those in group day care (GDC) and therefore to antibiotic treatment. Thus fewer CM children should carry resistant bacteria. To test this hypothesis nasopharyngeal carriage of Streptococcus pneumoniae (SP) and Haemophilus influenzae (HI) and exposure to recent antibiotic treatm...
Purpose: The hedgehog (HH) signaling pathway is a key regulator in tumorigenesis of pancreatic adenocarcinoma and is upregulated in pancreatic adenocarcinoma cancer stem cells (CSCs). GDC-0449 is an oral small-molecule inhibitor of the HH pathway. This study assessed the effect of GDC-0449–mediated HH inhibition in paired biopsies, followed by combined treatment with gemcitabine, in patients wi...
PURPOSE The hedgehog (HH) signaling pathway is a key regulator in tumorigenesis of pancreatic adenocarcinoma and is upregulated in pancreatic adenocarcinoma cancer stem cells (CSCs). GDC-0449 is an oral small-molecule inhibitor of the HH pathway. This study assessed the effect of GDC-0449-mediated HH inhibition in paired biopsies, followed by combined treatment with gemcitabine, in patients wit...
Purpose: GDC-0973 is a potent and selective MEK inhibitor. Pharmacokinetic-pharmacodynamic (PK-PD) modeling was used to relate GDC-0973 plasma and tumor concentrations, tumor pharmacodynamics (PD) and anti-tumor efficacy in order to establish pharmacokinetic endpoints and predict active doses in the clinic. Experimental Design: A PK-PD model was used to characterize GDC-0973 tumor disposition a...
The phosphatidylinositol 3-kinase (PI3K) pathway is a major determinant of cell cycling and proliferation. Its deregulation, by activation or transforming mutations of the p110alpha subunit, is associated with the development of many cancers. 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) is a novel small molecule inhibitor of ...
Using cost-effective fabrication methods to manufacture a high-performance solid oxide fuel cell (SOFC) is helpful enhance the commercial viability. Here, we report an anode-supported SOFC with three-layer Gd0.1Ce0.9O1.95 (gadolinia-doped-ceria [GDC])/Y0.148Zr0.852O1.926 (8YSZ)/GDC electrolyte system. The first dense GDC fabricated by co-sintering thin, screen-printed layer anode support (NiO–8...
A three-dimensional Guglielmi detachable coil (3D-GDC) has been developed that is designed specifically to bridge the neck of an aneurysm with coil loops, thereby facilitating retention of additional coils placed within the aneurysm. Nine wide-necked cerebral aneurysms were successfully embolized using the 3D-GDC, provided that the dome-to-neck ratio was 1.5 or greater.
Glioblastomamultiforme (GBM) is a highlymalignant human brain neoplasmwith limited therapeutic options. GBMs display a deregulated apoptotic pathway with high levels of the antiapoptotic Bcl-2 family of proteins and overt activity of the phosphatidylinositol 3-kinase (PI3K) signaling pathway. Therefore, combined interference of the PI3K pathway and the Bcl-2 family of proteins is a reasonable t...
Purpose: Docetaxel is a front-line standard-of-care chemotherapeutic drug for the treatment of breast cancer. Phosphoinositide 3-kinases (PI3K) are lipid kinases that regulate breast tumor cell growth, migration, and survival. The current study was intended to determine whether GDC-0941, an orally bioavailable class I selective PI3K inhibitor, enhances the antitumor activity of docetaxel in hum...
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