The success in the preparation of Eudragit RS100 microspheres in 0.IN HCI solution using gelatin as antiaggregating agent, encouraged the selection of an acidic drug to be encapsulated using a solvent evaporation technique [1]. Ibuprofen is a non-steroidal, anti-inflammatory, analgesic and antipyretic drug approved for use as adjunct therapy in the treatment of rheumatoid and osteoarthritis [2]...

Microspheres formulated from poly (D,L-lactic-co-glycolide) (PLGA), a biodegradable polymer, have been extensively evaluated as a drug delivery system. In this study, the preparation, characterization and drug release properties of the PLGA microspheres were evaluated. Simvastatin (SIM)-loaded PLGA microspheres were prepared by oil-in-water emulsion/solvent evaporation method. The microspheres ...

Cell sorting is an essential and efficient experimental tool for the isolation and characterization of target cells. A three-dimensional environment is crucial in determining cell behavior and cell fate in biological analysis. Herein, we have applied photodegradable hydrogels to optical cell separation from a 3D environment using a computer-controlled light irradiation system. The hydrogel is c...

+*Nagae, M; *Ikeda, T; *Mikami, Y; *Sawamura, K; *Hase, H; **Ozawa, H; *** Tabata, Y; **** Kawata, M; *Kubo, T +*Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine **Department of Anatomy and Neurobiology, Nippon Medical School ***Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto Universi...

The objective of this study was to formulate and evaluate the drug-polymer interaction of mefenamic acid (MA) using two polymers with different characteristics as ethylcellulose (EC) and/or cellulose acetate phthalate (CAP). Microspheres were prepared by the modified emulsion solvent evaporation (MESE). The effect of drug-polymer interaction was studied for each of microspheres. Important param...