The role of diet in the prevention of breast cancer is widely accepted, yet little is known about how its biological effects mitigate susceptibility to this disease. Soy consumption is associated with reduced breast cancer risk in women, an effect largely attributed to the soy isoflavone genistein (Gen). We previously showed reduced incidence of chemically induced mammary tumors in young adult ...

Although cisplatin (DDP) has been reported to be a promising antitumor therapy for non-small cell lung cancer (NSCLC), the effectiveness of the treatment remains limited due to an inherent tumor resistance to DDP. Genistein (GEN) is an abundant, naturally occurring isoflavonoid found in soy products that has been demonstrated to increase the anti-neoplastic activity of certain chemotherapy drug...

Revision of the Neotropical genera of the subtribe Anthaxiina Gory & Laporte, 1839 (Coleoptera, Buprestidae, Buprestinae, Anthaxiini). Five new genera are described: Anthaxita gen. n., Charlesina gen. n., Cobosina gen. n., Marikia gen. n. and Sanchezia gen. n. Genus Agrilaxia Kerremans, 1903 is divided into two subgenera: Agrilaxia and Costiptera subgen. n. and the genus Bilyaxia Hołyński, 1989...

A perforated patch recording method was used to determine the effects of genistein (Gen), a protein tyrosine kinase (PTK) inhibitor, on basal L-type Ca2+ current ( I Ca,L) in feline atrial myocytes. Gen (50 μM) elicited biphasic changes in I Ca,L: an initial inhibition (-55 ± 4%; phase 1) followed by a secondary stimulation (34 ± 9%; phase 2) of I Ca,L. Withdrawal of Gen elicited a further pote...

Genistein (GEN) is an isoflavone known to inhibit both tyrosine protein kinases and DNA topoisomerase II. The effects of GEN on cell proliferation and cell cycle kinetics of human myelogenous leukemia HL-60 and lymphocytic leukemia MOLT-4 cell cultures were studied, and the data were compared to results obtained with normal human lymphocytes stimulated to proliferate with phytohemagglutinin. GE...

Wang, Yong G., and Stephen L. Lipsius. Genistein elicits biphasic effects on L-type Ca21 current in feline atrial myocytes. Am. J. Physiol. 275 (Heart Circ. Physiol. 44): H204–H212, 1998.—A perforated patch recording method was used to determine the effects of genistein (Gen), a protein tyrosine kinase (PTK) inhibitor, on basal L-type Ca21 current (ICa,L) in feline atrial myocytes. Gen (50 μM) ...

Terrestrial and aquatic gastropods from the upper Eocene (Priabonian) Zalumah Formation in the Salalah region of the Sultanate of Oman are described. The assemblages reflect the composition of the continental mollusc fauna of the Palaeogene of Arabia, which, at that time, formed parts of the southeastern Tethys coast. Several similarities with European faunas are observed at the family level, b...

We address the problem of integrating heterogeneous data sources for collaborative environments such as Groupware systems. Pre-existing related distributed data is modeled by a composite object, where each data source is treated as a fragment of the composite object. We define a collection of methods which allow manipulation of the related distributed data in a controlled and consistent manner....

Diketopyrrolopyrrole (ACQ-gen) and tetraphenylethenes (AIE-gen) are linked together with phenyl bridges. The derivatives show substantially enhanced and red-shifted emission in the solid state.

Neonatal infections are a leading cause of childhood mortality in low-resource settings. World Health Organization guidelines for outpatient treatment of possible serious bacterial infection (PSBI) in neonates and young infants when referral for hospital treatment is not feasible include intramuscular gentamicin (GEN) and oral amoxicillin. GEN is supplied as an aqueous solution of gentamicin su...