Gene duplication is an important evolutionary mechanism that can result in functional divergence in paralogs due to neo-functionalization or sub-functionalization. Consistent with functional divergence after gene duplication, recent studies have shown accelerated evolution in retained paralogs. However, little is known in general about the impact of this accelerated evolution on the molecular f...

the combustion of sulfur-rich fossil fuels leads to the release of acid rain-causing sulfurdioxide into the environment. the aim of this study was to enhance the efficiency of biodesulfurizationusing pseudomonas aeruginosa through the duplication of the dsz cluster in this organism. one copy ofthe dsz cluster was inserted by a tri-parental mating method into the chromosome of pseudomonasaerugin...

Genome duplication is a powerful evolutionary force and is arguably most prominent in plants, where several ancient whole-genome duplication events have been documented. Models of gene evolution predict that functional divergence between duplicates (subfunctionalization) is caused by the loss of regulatory elements. Studies of conserved non-coding sequences (CNSs), which are putative regulatory...

What are the evolutionary consequences of gene duplication? One answer is speciation, according to a model initially called Reciprocal Silencing and recently expanded and renamed Divergent Resolution. This model shows how the loss of different copies of a duplicated gene in allopatric populations (divergent resolution) can promote speciation by genetically isolating these populations should the...

The majority of protein architectures exhibit elements of structural symmetry, and "gene duplication and fusion" is the evolutionary mechanism generally hypothesized to be responsible for their emergence from simple peptide motifs. Despite the central importance of the gene duplication and fusion hypothesis, experimental support for a plausible evolutionary pathway for a specific protein archit...

Gene duplication is often cited as a potential mechanism for the evolution of new traits, but this hypothesis has not been thoroughly tested experimentally. A classical model of gene duplication states that after gene duplication one copy of the gene preserves the ancestral function, while the other copy is free to evolve a new function. In an alternative duplication, divergence, and complement...

Gene duplication has long been recognized as a major force in genome evolution and has recently been recognized as an important source of individual variation. For many years, the origin of functional gene duplicates was assumed to be whole or partial genome duplication events, but recently retrotransposition has also been shown to contribute new functional protein coding genes and siRNA's. In ...

The fact that there are four homeobox (Hox) clusters in most vertebrates but only one in invertebrates is often cited as evidence for the hypothesis that two rounds of genome duplication by polyploidization occurred early in vertebrate history. In addition, it has been observed in humans and other mammals that numerous gene families include paralogs on two or more of the four Hox-bearing chromo...

This work describes a family with Duchenne muscular dystrophy (DMD) rare case of symptomatic pregnant woman. The main aim was to perform prenatal molecular diagnosis provide genetic counseling. secondary suggest the mechanisms causing complex structural variant (cxSV) identified. To accomplish this, we used multi-technique algorithm including segregation analysis, Multiplex Ligation-dependent P...

Objective: Dystrophinopathies are the most frequently researched neuromuscular disease group due to their characteristic and diverse clinical genetic spectrum. This study aims evaluate deletion duplication profile of dystrophin gene in Turkey by investigating data from a tertiary center. Material Methods: Dystrophin MLPA microarray results 53 patients, 49 with dystrophinopathy 4 neurogenetic sy...