Proteomic research has proved valuable for understanding the molecular mechanisms of biological processes, as well as in the search for biomarkers for a variety of diseases which lack a molecular diagnostic. While several new approaches are being developed, two-dimensional (2-DE) gel electrophoresis is still one of the most commonly used techniques, despite its many limitations. However, for bi...

The treatment of painful chronic pancreatitis remains controversial. The available evidence from two randomized controlled trials favor surgical intervention, whereas an endotherapy-first approach is widely practiced. Chronic pancreatitis is complex disease with different genetic and environmental factors, different pain mechanisms and different treatment modalities including medical, endoscopi...

The research undertaken describes a regional health authority's approach to managing a shift away from acute hospital care towards more community-based, health promoting service orientations in line with new legislated responsibilities. It builds on earlier research of province-wide efforts to create new ways of organizing work within new regional health authority structures. The initial study ...

Good design and implementation are necessary but not sufficient pre-requisites for the successful reuse of object-oriented frameworks. Although not always recognized, good documentation is crucial for effective framework reuse, and comes with many issues. Defining and writing good quality documentation for a framework is often hard, costly, and tiresome, especially when not aware of its key pro...

A Generalized Framework for Kerberos Pre-Authentication draft-ietf-krb-wg-preauth-framework-04 Status of this Memo By submitting this Internet-Draft, each author represents that any applicable patent or other IPR claims of which he or she is aware have been or will be disclosed, and any of which he or she becomes aware will be disclosed, in accordance with Section 6 of BCP 79. Internet-Drafts a...

We address the issue of when generalized quantum dynamics, which is a classical symplectic dynamics for noncommuting operator phase space variables based on a graded total trace Hamiltonian H, reduces to Heisenberg picture complex quantum mechanics. We begin by showing that when H = TrH , with H a Weyl ordered operator Hamiltonian, then the generalized quantum dynamics operator equations of mot...

Practical implementation of new P2P streaming systems requires a lot of coding and is often tedious and costly, slowing down the technology transfer from the research community to real users. GRAPES aims at relieving this burden, and speed-up application development, by providing a set of open-source components conceived as basic building blocks for building new P2P streaming applications. GRAP...

This paper will start with an introduction into PCI Express architecture. It will highlight what the pre-requisites for testing PCI Express are and what test strategies have to be followed for testing this type of device efficiently. Besides the raw speed support and the adaptation to embedded clock interface specifics, emphasis will be put on the protocol induced difficulties for high volume t...

The Kutch Earthquake of January 26, 2001 in Gujarat, India, caused the destruction of a large number of modern 4 to 10-storied buildings. After this earthquake, doubts arose about our professional practices, building by-laws, construction materials, building codes and education for civil engineers and architects. It led to large number of short-term courses and workshops, revision of the seismi...

LY2157299 (LY), which is very small molecule bringing high cancer diffusion, is a pathway antagonist against TGFβ. LY dosage can be diluted by blood plasma, can be captured by immune system or it might be dissolved during digestion in gastrointestinal tract. The aim of our study is to optimize a "nano-elastic" carrier to avoid acidic pH of gastrointestinal tract, colon alkaline pH, and anti-imm...