نتایج جستجو برای: genetic adjuvant
تعداد نتایج: 656950 فیلتر نتایج به سال:
Background Endocrine therapy is an effective treatment of estrogen receptor-positive (ER+) breast tumors, significantly reducing mortality. However, approximately 30% of patients receiving adjuvant endocrine therapy will experience recurrence within a 15-year period. The mechanisms of endocrine resistance are poorly understood. Understanding the underlying genetic diversity of breast cancers re...
Until themid-1990s, postoperative adjuvant radiation therapy was considered the standard of care in management of operable rectal cancer (1). Although several investigators had demonstrated improvements in local recurrence rates, better options for sphincter preservation, improved survival, and lower toxicities, it was impossible to undertake and complete prospective studies of preoperative (ne...
BACKGROUND This multicenter study was performed to develop a prognosis-prediction model incorporating genetic polymorphism with pathologic stage for surgically treated non-small cell lung cancer (NSCLC) patients. METHODS A replication study including 720 patients and a panel of eight single nucleotide polymorphisms (SNPs), which predicted the prognosis of surgically treated NSCLC in our previ...
an adjuvant is a substance that is added to a vaccine to increase the body's immune response to the vaccine. vaccines containing adjuvants are tested for safety in clinical trials before they are licensed for used. the basic action of adjuvants is stimulating adaptive immune responses. adjuvants, recently licensed for human utlization, involve alum squalane oil or water emulsion, influenza viro...
Skin is a unique target for vaccination. Targeting keratinocytes to produce proinflammatory mediators improve immunity rational approach vaccine design. Keratinocytes genetically engineered overexpress the stress response related transcription factor x-box binding protein 1 (XBP1) increased production of and co-delivered antigen. Keratinocyte-specific overexpression XBP1 through cutaneous genet...
implicit and unobserved errors and vulnerabilities issues usually arise in cryptographic protocols and especially in authentication protocols. this may enable an attacker to make serious damages to the desired system, such as having the access to or changing secret documents, interfering in bank transactions, having access to users’ accounts, or may be having the control all over the syste...
calcium mobilization is known to be an important factor in the activation of cells involved in inflammation,so,calcium-channel antagonists are be expected ti exhibit antiinflammatory activity.in the present study,we evaluateted the antiinflammatory effects of two calcium channel blockers,verapamil and nifedipine on adjuvant induced chronic in flammation in rat paw.sixty adult male rats were div...
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