We have recently demonstrated that inhibition of Rho GTPase with Clostridium difficile toxin B, or with Clostridium botulinum C3 toxin, causes actin depolymerization and translocation of aquaporin 2 (AQP2) in renal CD8 cells in the absence of hormonal stimulation. Here we demonstrate that Rho inhibition is part of the signal transduction cascade activated by vasopressin leading to AQP2 insertio...

This paper presents three systems submitted to the German Dialect Identification (GDI) task at the VarDial Evaluation Campaign 2017. The task consists of training models to identify the dialect of SwissGerman speech transcripts. The dialects included in the GDI dataset are Basel, Bern, Lucerne, and Zurich. The three systems we submitted are based on: a plurality ensemble, a mean probability ens...

X-linked intellectual disability (XLID) has been associated with various genes. Diagnosis of XLID, especially for non-syndromic ones (NS-XLID), is often hampered by the heterogeneity of this disease. Here we report the case of a Chinese family in which three males suffer from intellectual disability (ID). The three patients shared the same phenotype: no typical clinical manifestation other than...

PURPOSE The purpose of our study was to investigate the effect of gait training with rhythmic auditory stimulation (RAS) on both kinematic and temporospatial gait patterns in patients with hemiplegia. MATERIALS AND METHODS Eighteen hemiplegic patients diagnosed with either cerebral palsy or stroke participated in this study. All participants underwent the 4-week gait training with RAS. The tr...

The role of GDP dissociation inhibitor (GDI) protein in regulation of Rab cycle in Leishmania is not known. Here, we have cloned and characterized the functions of GDI homologue in vivo in Leishmania. Our results have shown that LdGDI:WT along with GDP removes the Rab5 from purified endosomes and inhibits the homotypic fusion between early endosomes. Whereas, LdGDI:R239A, a dominant negative mu...

Normal somatic cells enter a state of irreversible proliferation arrest-designated cellular senescence, which is characterized by biochemical changes and a distinctive morphology. Cellular stresses, including oncogene activation, can lead to senescence. Consistent with an antioncogenic role in this process, the tumor suppressor pRb plays a critical role in senescence. Reexpression of pRb in hum...

sunn pest (eurygaster integriceps put.) is one of the major pests of wheat in iran. identification of resistantcultivars is an effective integrated pest management (ipm) strategy. to identify the genetic response of wheat and triticale to sunn pest, and determine the relationship between resistance and morpho physiological traits, eight bread wheat breeding lines/cultivars, four durum wheat lin...

Corticosterone, themajor stress hormone, plays an important role in regulating neuronal functions of the limbic system, although the cellular targets and molecular mechanisms of corticosteroid signaling are largely unknown. Here we show that a short treatment of corticosterone significantly increases -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated synaptic transmis...

The Rho family of GTPases control actin organization during diverse cellular responses (migration, cytokinesis and endocytosis). Although the primary members of this family (RhoA, Rac and Cdc42) have different downstream effects on actin remodeling, the basic mechanism involves targeting to the plasma membrane and activation by GTP binding. Our hypothesis is that the details of GTPase cycling b...

in recent years, different damage indexes have been introduced in engineering literature. the most prominent one among other counterparts is the 1985 park and ang's damage index (dipa), which demonstrates well calibration against experimental results. hence, it has traditionally had broad application in the field of structural engineering. commonly, in dipa relevant parameters are assessed...