Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen whose virulence dependent on quorum sensing (QS). DksA1, an RNA polymerase-binding transcriptional regulator, plays role in determining number of phenotypes, including QS-mediated virulence. We therefore envisioned that DksA1 inhibitors may help to control P. infection. Here, we screened library 6970 chemical compounds and identif...
