Obrovskobuněčná arteriitida je nejčastěji se vyskytující vaskulitida u dospělých. Autor uvádí nejnovější poznatky v diagnostice i léčbě, zdůrazňuje rostoucí význam neinvazivních vyšetřovacích metod, kdy biopsie temporální arterie již nepokládá za jediné možné vyšetření potvrzující diagnózu. Zdůrazňuje důležitost včasné diagnostiky zahájení léčby....

Giant cell arteritis (GCA) is a systemic vasculitis of medium and large vessels. Corticotherapy is the cornerstone treatment, but most patients fail to reach remission or relapse during the weaning of Glucocorticoids (GC). Here we report 2 patients with corticoid dependent GCA, successfully treated with Tocilizumab (TCZ), with a rapid clinical and biological outcome allowing the tapering of GC,...

Definitive histological studies of giant-cell (temporal) arteritis have been published by several workers (Harrison, 1948; Heptinstall, Porter, and Barkley, 1954; McCormick and Neuberger, 1958). The lesions are fairly uniform and have involved all layers of many different arteries and veins-large and small, intracranial as well as extracranial. The distinctive histological finding in this disea...

This report provides a rare histological example and the appropriate management of spontaneous aortic dissection secondary to giant cell arteritis.

Nine elderly patients presented with features of a multisystem disorder thought to be either a connective tissue disease of undefined type or disseminated malignancy. Associated features were a normochromic anaemia, raised erythrocyte sedimentation rate (ESR) (or plasma viscosity) and raised serum alkaline phosphatase levels. None had symptoms to suggest either giant cell arteritis or polymyalg...

Giant-cell arteritis is associated with a higher risk of aortic aneurysm and aortic dissection formation. We present a women with aortic dissection type B treated with a stent graft and bare-metal stent implantation. After the stent deployment we noticed aortic rupture, which was successfully treated with implantation of an additional stent graft. This report highlights the difficulty of endova...

A 68-year-old man was admitted because of a pulsatile mass and pain in the left temporal region, and computed tomography demonstrated the superficial temporal artery aneurysm. He underwent aneurysmectomy, and pathologic investigation revealed marked thickness of the adventitia with substantial plasmacyte infiltration. On immunoglobulin G4 (IgG4) immunohistochemistry, IgG4-positive lymphocytes w...