Ingestion of aristolochic acid (AA) can cause AA nephropathy (AAN), in which excessive death of tubular epithelial cells (TECs) characterize the acute phase. AA forms adducts with DNA, which may lead to TEC apoptosis via p53-mediated signaling. We tested this hypothesis both by studying p53-deficient mice and by blocking p53 in TECs with its inhibitor pifithrin-alpha. AA induced acute AAN in wi...

The International Reference Ionosphere model 2001 (IRI-2001) is one of the most comprehensive empirical models of the ionosphere and has been widely used to estimate the electron density profiles in the altitude ranging from about 60 to 2000 km and the total electron content (TEC) at any given location, time and date, which reflect smooth-average global ionospheric behaviors. However, whether i...

There are significant controversies surrounding the detection of precursors that may precede earthquakes. Natural hazard signatures associated with strong earthquakes can appear in lithosphere, troposphere, and ionosphere, where current remote sensing technologies have become valuable tools for detecting measuring early warning signals stress build-up deep Earth’s crust (presumably earthquake e...

in this study, it was surveyed to know whether an oral single dose of oleuropein could mimic the cardiac preconditioning in rats’ hearts or whether its prolonged oral administration could protect the heart against the aconitine-induced arrhythmia in rats. eighty male wistar rats were divided into two series (n = 8 in each group). in the first series, all groups (except the control (con) group) ...

The thymus exhibits a pattern of aging oriented toward a physiological involution. The structural changes start with a steady decrease of thymocytes, whereas no major variations occur in the number of thymic epithelial cells (TEC). The data concerning the role of hormones and neuropeptides in thymic involution are equivocal. We recently demonstrated the presence of somatostatin (SS) and three d...

Modeling ionospheric variability throughout a proper total electron content (TEC) parameter estimation is demanding, however, crucial, process for achieving better accuracy and rapid convergence in precise point positioning (PPP). In particular, the single-frequency PPP (SF-PPP) method lacks due to difficulty of dealing adequately with error sources. order apply ionosphere corrections technique...

water quality is a worldwide problem which affects human beings lives fundamentally. water scarcity is intensified in result of quality deterioration. different factors such as population increase, economic development and water pollution could be considered as the origins of the problem. the study and forecasting of water quality is necessary to prevent serious water quality deteriorations in ...

this paper presents the prediction of vehicle's velocity time series using neural networks. for this purpose, driving data is firstly collected in real world traffic conditions in the city of tehran using advance vehicle location devices installed on private cars. a multi-layer perceptron network is then designed for driving time series forecasting. in addition, the results of this study a...