نتایج جستجو برای: gli1

تعداد نتایج: 1131  

2010
Akil Merchant Giselle Joseph Qiuju Wang Sarah Brennan William Matsui

The Hedgehog (Hh) pathway is essential for normal embryonic development and tissue repair. The role of Hh signaling in hematopoiesis has been studied primarily by modulating the activity of Patched and Smoothened, but results have been conflicting. Some studies demonstrate a requirement for pathway activity in hematopoiesis, whereas others report that it is dispensable. Hh activity converges on...

2009
Jay Joo Laura Christensen Kegan Warner Leith States Hyung-Gyoo Kang Kieuhoa Vo Elizabeth R. Lawlor William A. May

The Ewing Sarcoma Family Tumors (ESFT) consist of the classical pathologic entities of Ewing Sarcoma and peripheral Primitive Neuroectodermal Tumor. Occurring largely in the childhood through young adult years, these tumors have an unsurpassed propensity for metastasis and have no defined cell of origin. The biology of these aggressive malignancies centers around EWS/FLI1 and related EWS/ETS ch...

2011
Tapati Mazumdar Jennifer DeVecchio Akwasi Agyeman Ting Shi Janet A. Houghton

The Hedgehog (HH) signaling pathway leads to activation of GLI, which transcriptionally regulate target genes. Regulated HH signaling activity is critical during embryogenesis while aberrantly activated HH signaling is evident in a variety of human cancers. Canonical HH signaling engages the transmembrane receptor Patched (PTCH) and the signaling intermediate Smoothened (SMO) to activate GLI1 a...

2016
Monica Benvenuto Laura Masuelli Enrico De Smaele Massimo Fantini Rosanna Mattera Danilo Cucchi Elena Bonanno Enrica Di Stefano Giovanni Vanni Frajese Augusto Orlandi Isabella Screpanti Alberto Gulino Andrea Modesti Roberto Bei

Aberrant Hedgehog (Hh)/glioma-associated oncogene (GLI) signaling has been implicated in cancer progression. Here, we analyzed GLI1, Sonic Hedgehog (Shh) and NF-κB expression in 51 breast cancer (ductal carcinoma) tissues using immunohistochemistry. We found a positive correlation between nuclear GLI1 expression and tumor grade in ductal carcinoma cases. Cytoplasmic Shh staining significantly c...

2014
Akwasi Agyeman Babal K Jha Tapati Mazumdar Janet A Houghton

The GLI genes, GLI1 and GLI2, are transcription factors that regulate target genes at the distal end of the canonical Hedgehog (HH) signaling pathway (SHH->PTCH->SMO->GLI), tightly regulated in embryonic development, tissue patterning and differentiation. Both GLI1 and GLI2 are oncogenes, constitutively activated in many types of human cancers. In colon cancer cells oncogenic KRAS-GLI signaling...

2015
Yi-Lin Yang Jian Ni Ping-Chih Hsu Jian-Hua Mao David Hsieh Angela Xu Geraldine Chan Alfred Au Zhidong Xu David M Jablons Liang You

Malignant pleural mesothelioma (mesothelioma) is a highly aggressive cancer without an effective treatment. Cul4A, a scaffold protein that recruits substrates for degradation, is amplified in several human cancers, including mesothelioma. We have recently shown that Cul4A plays an oncogenic role in vitro and in a mouse model. In this study, we analysed clinical mesothelioma tumours and found mo...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2012
Yandong Shi Ubiratan Moura Isabelle Opitz Alex Soltermann Hubert Rehrauer Svenja Thies Walter Weder Rolf A Stahel Emanuela Felley-Bosco

PURPOSE The aim of this study was to assess the activity of hedgehog signaling pathway in malignant pleural mesothelioma (MPM). EXPERIMENTAL DESIGN The expression of hedgehog signaling components was assessed by quantitative PCR and in situ hybridization in 45 clinical samples. Primary MPM cultures were developed in serum-free condition in 3% oxygen and were used to investigate the effects of...

2017
Wang Feng Xuan Xiaoyan Li Shenglei Liu Hongtao Jiang Guozhong

Pituitary tumor-transforming gene-1 (PTTG1) could acquire its metastasis-promoting effects via inducing epithelial-mesenchymal transition (EMT). However, its role and mechanism in EMT in esophageal squamous cell cancer (ESCC) had not been clearly elucidated. Here, we demonstrated that PTTG1 was overexpressed in ESCC cell lines and tissues especially those with lymph node metastasis. Down regula...

2017
Alok Ranjan Sanjay K. Srivastava

Glioblastoma (GBM) is the most common brain tumor with poor survival rate. Our results show that penfluridol, an antipsychotic drug significantly reduced the survival of ten adult and pediatric glioblastoma cell lines with IC50 ranging 2-5 μM after 72 hours of treatment and induced apoptosis. Penfluridol treatment suppressed the phosphorylation of Akt at Ser473 and reduced the expression of GLI...

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