Anti-glomerular basement membrane (GBM) disease usually pursues a self-limited course, at least from the immunological perspective. In addition, circulating antibodies to cryptic, conformational epitopes within the NC1 domain of the alpha 3 chain of Type IV Collagen are commonly found at the zenith of the clinical disease. However, exceptions to these general rules do occur, as exemplified by t...

Goodpasture’s disease (also known as Goodpasture syndrome, anti-glomerular basement membrane disease, anti-GBM disease) is an uncommon yet well known condition because of the striking way in which it can cause rapid destruction of the kidneys and bleeding into the lungs. A patient with this syndrome was first described by Ernest Goodpasture in 1919. However, it is now known that several disease...

Dogs were randomly assigned to experimental galactosemia or diabetes, or to a normal untreated group, and diabetic animals were then randomly assigned to either poor or good glycemic control. At five years duration, kidneys from the animals were compared by quantitative stereology. Glomerulopathy appeared in the poor control diabetes group, and the thickness of glomerular capillary basement mem...

BACKGROUND AND OBJECTIVES Approximately 20%-30% of patients with anti-glomerular basement membrane disease present coexisting anti-myeloperoxidase (MPO) autoantibodies. We previously showed the recognition of a linear fragment of the MPO heavy chain N-terminus ((1)H, MPO279-409) in plasma from most double-positive patients. Herein, we investigated the frequency of autoantibodies against overlap...

Sections of mouse renal glomerulus fixed by perfusion with buffered osmium tetroxide solution have been studied with the electron microscope. Four components are recognized in the mouse glomerulus: epithelium, basement membrane, endothelium, and intercapillary cell. The three cellular components all display in their cytoplasm mitochondria, Golgi bodies, endoplasmic reticulum, and uncharacterize...

Glomerular and other vascular basement membranes were found to contain an antigen that was immunochemically indistinguishable from serum amyloid P-component. There was no immunological cross-reactivity between antisera to serum amyloid P-component and to collagen types I, III, IV, or V. The amyloid P-component antigen was confined to the endothelial aspect, the lamina rara interna, of glomerula...

Studies of the pathogenesis of glomerular disease have suggested that polymorphonuclear leucocytes promote glomerular damage. The pattern of events observed in the autologous phase of nephrotoxic serum nephritis in rabbits indicates that the fixation of antibodies to glomerular basement membrane initiates the activation and binding of complement. This results in the chemotaxis of polymorphonucl...