1. Glomerular filtration rate and effective renal blood-flow were normal in a series of patients with sickle cell anaemia. Fractional creatinine excretion and fractional urea excretion were increased. 2. During indomethacin administration there were significant falls in glomerular filtration rate, effective renal blood-flow, creatinine clearance and urea clearance in the patients with sickle ce...

In addition to direct measurement methods of glomerular filtration rate, there are many formulas whose purpose is to estimate glomerular filtration rate from endogenous markers, of which the most used is serum creatinine. The latest recommendations the French health agency Haute Autorité de santé (HAS) unambiguously endorse the use of the CKD-EPI equation. The assessment of glomerular filtratio...

● Patients with kidney disease have few signs and symptoms early in disease course; laboratory evaluation may be only way of detecting disease ● Tests should detect abnormalities early enough to allow corrective therapy ● Important for measuring renal disease progression and efficacy of therapies ● Help predict when renal replacement therapy may be necessary ● Aid in appropriate dosing of medic...

After giving oral frusemide (Lasix) to 14 normal volunteers significant hypercalciuria occurred in all of them. This could not be accounted for by any change in glomerular filtration rate, but was possibly due to decreased tubular reabsorption.

We compared creatinine concentrations in serum and urine and creatinine clearances determined by two Jaffé (Beckman's "Astra," Boehringer Mannheim Diagnostics) and two enzymatic (Kodak, Boehringer Mannheim Diagnostics) methods. Serum creatinine and creatinine clearances determined by each method were also compared with the glomerular filtration rate as measured with use of sodium [125I]iothalam...

Inulin clearance is still considered as the gold standard method to measure glomerular filtration rate. This method has been proposed in thirties by Smith and Shannon but the inulin measurement method still remains complex. Interferences, notably with the glucose, must also be considered. Two main methods have been proposed to measure inulin both in urine and plasma: "acid" or enzymatic methods...