Catalytic effect of hydroxypropyl cellulose, hydroxypropylmethyl cellulose, glyceryl behenate and magnesium stearate in the presence of 50.9% - 76.4% humidity at 318 K on stability of quinapril hydrochloride (QHCl) was examined by HPLC method. The differences in kinetic mechanism of degradation of QHCl were observed. The effect of humidity on QHCl stability in the presence of hydroxypropyl cell...

The oxidation of N-hydroxylated compounds may result in production of nitrogen oxides, including nitric oxide (NO). Oxidation may be independent on NO-synthase. Production of nitrites and nitrates via NO from formaldoxime and glyceryl trinitrate was studied and compared. Superoxide ion, ions Fe2+ and Fe3+, methemoglobin and methemoglobin + NADPH + methylene blue, oxyhemoglobin and oxyhemoglobin...

1. The isolated stomachs of the dogfish, Squdus acanthias, and the skate, Raja erinacea, were found to incorporate long chain alcohols and acetate, but not long chain fatty acids, into glyceryl ethers. 2. The criterion for evaluation of incorporation of radioactive substrates into glyceryl ethers was the measurement of activity of individual isopropylidene derivatives separated by means of gas-...

Twenty-four patients with angina pectoris entered a double-blind trial of the cardioselective beta-adrenergic blocking agent practolol. Seventeen experienced less angina and consumed fewer glyceryl trinitrate tablets when on the active preparation. There was also a decrease in the mean number of attacks suffered by patients while on practolol and a reduction in the number of glyceryl trinitrate...

MR. J. PICKTHALL.' When talking of H.L.B. values, the speaker has referred to the oil solubility of calcium soaps. Are these soaps in fact oil soluble in the sense that we are considering ? In discussing the emulsifying action of the calcium soaps, the speaker has compared them with glyceryl distearate and aluminium stearate. Glyceryl distearate is indeed oil soluble but commercial aluminium st...

(a) Penicillin.-Most significant developments have taken place in the field of antibiotics, especially with repository penicillins. The treatment, which used to consist of injections every 2 to 4 hours with aqueous penicillins, daily with penicillin in oil-beeswax, and sometimes once or twice weekly with procaine penicillin with aluminium monostearate, may now be achieved by a single or a few i...

The control of syphilis in Bosnia was organised and started by Professor Ernest Grin in 1948 and continued to the end of 1951. Regardless of the clinical picture, the treatment of endemic syphilis consisted of an oil suspension of penicillin with aluminium monostearate (PAM) 3.6 to 4.2 MIU for adults in six or seven intramuscular injections of 0.6 MIU every day or 1.2 MIU every other day. Today...