A half century ago, Goldblatt described the effect of renal ischemia on blood pressure. Motivated by inadequate pharmacological therapies for hypertension (HBP), the substantial risks of persistently elevated blood pressure, and the possibility of curing an important disease, clinicians soon thereafter sought to apply Goldblatt's findings, initially by removal of suspected culprit kidneys and l...

1. The role of vasopressin in blood pressure control and in the pathogenesis of one-kidney Goldblatt hypertension in the conscious dog was investigated. 2. Infusion of synthetic arginine vasopressin to elevate plasma levels approximately five-fold caused bradycardia in normal dogs and increase in mean arterial blood pressure in dogs with pharmacological autonomic blockade. 3. A similar degree o...

The effects of renal denervation on the onset and maintenance of one-kidney, one clip Goldblatt (1K1C) hypertension were determined. Renal denervation was performed at the time of 1K1C surgery, and was repeated at 3-week intervals to prevent renal nerve regeneration. Denervation delayed the onset of 1K1C hypertension by about 5 weeks, but the final hypertensive state was unaltered. Mean arteria...

In opening his address the speaker reviewed the history of hypertensive disease. Richard Bright considered hypertension was secondary to nephritis, Sir Clifford Allbutt showed that in the majority of cases there is no clinical evidence to support that view: what he named " hyperpiesia " is now called benign essential hypertension. Goldblatt produced hypertension in the dog by partially occludin...

Atherosclerotic renovascular disease (ARVD) is a major cause of secondary hypertension, especially in the elderly population. ARVD typically involves the proximal third of the renal artery including the perirenal aorta and ostium. The prevalence of ARVD is about 6.3–6.8 % in patients undergoing angiography or as determined in a population-based study utilizing a noninvasive screening technique ...

BACKGROUND Hypertension is a major public health epidemic that is highly associated with sexual dysfunction in both men and women. Despite its high prevalence, clinical and animal literature on the underlying mechanisms of sexual dysfunction in hypertensive women is remarkably limited. METHODS Using a well-established rodent model of renovascular hypertension-the 2-kidney, 1-clip (2K1C) Goldb...

Utilizing the stumptail macaque, we studied the atherosclerotic lesions produced in the aorta and coronary arteries by an atherogenic diet alone and by the diet coupled with hypertension produced by a modified Goldblatt technique. One group of monkeys was subjected concomitantly to the diet and hypertension for 10-12 months; a second group was on the diet for 29-32 months, but hypertension was ...