Central precocious puberty (CPP) is due to the premature activation of hypothalamic–pituitary–gonadal axis, which responsible for appearance secondary sexual characteristics. It occurs before age 8 and 9 in girls boys, respectively. CPP shows higher incidence females than males. Causes are similar both sexes, but idiopathic form more frequent girls, while organic forms Recent studies demonstrat...

Gonadal androgen suppression (castration via orchiectomy or gonadotropin-releasing hormone analogues) suppresses circulating testosterone levels but does not achieve adequate androgen ablation within the prostate cancer microenvironment because it does not address adrenal and intratumoral steroid contributions. These residual extragonadal sources of androgens allow prostate cancer cells to surv...