The denaturation of chorionic gonadotropin in 40 per cent aqueous urea solution has been found exceptional with respect to both the heat of activation and entropy of activation, but similar to other protein denaturations when compared on the basis of free energy of activation (1). The low rate (2) of inactivation of mare serum gonadotropin in 40 per cent aqueous urea solution at 37.5”, along wi...

We have observed that levels of the antioxidant glutathione (GSH) and protein levels of the catalytic and modifier subunits of the rate-limiting enzyme in GSH synthesis, GCLc and GCLm, increase in immature rat ovaries after treatment with gonadotropin. The goals of the present studies were to delineate the time course and intraovarian localization of changes in GSH and GCL after pregnant mare's...

This study was conducted with two experiments to investigate the efficacy of intravaginal antibiotic or their combination different gonadotropin use on vaginitis and fertility in Berrichon ewes. All ewes (n = 106) were synchronized sponges containing 60 mg medroxyprogesterone acetate for 14 days. For first experiment, 50) received 50 enrofloxacin (TRT) sponge prior insertion no treatment (CON) ...

A young woman with an occult bronchogenic carcinoma presented with secondary amenorrhea and an elevated beta subunit of human chorionic gonadotropin that was mistakenly attributed to pregnancy. Physicians should be aware that this carcinoma may present solely with an elevated beta human chorionic gonadotropin value, and the potential exists for confusion with a pregnancy state in women of child...

background: our objective was to evaluate the effectiveness of clomiphene citrate (cc) vs. letrozole (l) plus human menopausal gonadotropin (hmg) in gonadotropin releasing hormone (gnrh) antagonist protocol in poor prognosis women with previous failed ovarian stimulation undergoing intracytoplasmic sperm injection (icsi). materials and methods: this retrospective cohort study included cycles wi...

Abbreviations: HCG: Human Chorionic Gonadotropin; Β-hCG: Β-Human Chorionic Gonadotropin; DVT: Deep Vein Thrombosis; TMP-SMX: Trimethoprim and Sulfamethoxazole; EBV: Epstein Barr Virus; ALT: Alanine Aminotransferase; AST: Aspartate Aminotransferase; ALP: Alkaline Phosphatase, PT: Prothrombin Time; CBC: Complete Blood Cell; AFLP: Acute Fatty Liver of Pregnancy; DKA: Diabetic Ketoacidosis; GTD: Ge...

Early growth response factor (Egr-1) is an inducible zinc finger transcription factor that binds specific GC-rich enhancer elements and impacts female reproduction. These studies document for the first time that FSH rapidly induces Egr-1 expression in granulosa cells of small growing follicles. This response is transient but is reinitiated in preovulatory follicles exposed to the LH analog, hum...

The time course of chorionic gonadotropin stimulation of nuclear basic and acidic protein biosynthesis, phosphorylation, and acetylation as well as DNA biosynthesis in ovaries of immature rats has been investigated. After injection of radioactive precursor and chorionic gonadotropin into immature rats, ovarian histone fractions Fl, FZal, F2a2, F2b, and F3 were isolated by selective acid extract...