The effect of different leukocyte antibodies on the fate in vivo of granulocytes is not known. Thus, the optimum in vitro serologic tests to determine a safe and effective granulocyte transfusion or to diagnose immune destruction of granulocytes in other clinical situations have not been identified. We have studied the effect of granulocyte agglutinating (GA), granulocytotoxic (GC), and lymphoc...

A patient with well documented cyclic neutropenia (CN) was given chronic lithium therapy as well as a short course of plasmapheresis with therapeutic intention. While on lithium therapy. an increase in the amplitude of the granulocyte oscillations was observed. but recurrent agranulocytotic periods persisted. A 2-wk course of plasmapheresis (total exchange 1 7 liters) resulted in a gradual decr...

A patient with well documented cyclic neutropenia (CN) was given chronic lithium therapy as well as a short course of plasmapheresis with therapeutic intention. While on lithium therapy. an increase in the amplitude of the granulocyte oscillations was observed. but recurrent agranulocytotic periods persisted. A 2-wk course of plasmapheresis (total exchange 1 7 liters) resulted in a gradual decr...

Granulocyte mobilization into skin abrasions in human volunteers was significantly inhibited by acute alcohol intoxication (45,-800 cells in 8 hr versus 353,000 in normal controls). Alcohol applied locally did not inhibit granulocyte delivery, and protection of the abrasion against heat loss did not reduce the inhibited delivery in intoxicated volunteers. Intoxication inhibited granulocyte adhe...

BACKGROUND Despite modern antimicrobials and supportive therapy, bacterial and fungal infections are still major complications in people with prolonged disease-related or therapy-related neutropenia. Since the late 1990s there has been increasing demand for donated granulocyte transfusions to treat or prevent severe infections in people who lack their own functional granulocytes. This is an upd...

Aim: Community-acquired pneumonia (CAP) is a disease that affects children. One hundred fifty-five million children under five years are diagnosed with yearly, 20 hospitalized, and 2 die. Early diagnosis severity assessment reduce mortality morbidity. This study aimed to determine the effect of basic hemogram parameters, neutrophil-lymphocyte ratio (NLR), immature (IG) granulocyte, granulocyte ...