grn reverse engineering models

VAQUITA allows developers to reverse engineer a presentation model of a web page according to multiple reverse engineering options. The alternative models offered by these options not only widen the spectrum of possible presentation models but also encourage developers in exploring multiple reverse engineering strategies. The options provide filtering capabilities in a static analysis of HTML c...

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Reverse engineering in shipbuilding

Journal: :Mechanik 2015

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Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration.

Journal: :Archives of neurology 2011

Alice S Chen-Plotkin Maria Martinez-Lage Patrick M A Sleiman William Hu Robert Greene Elisabeth McCarty Wood Shaoxu Bing Murray Grossman Gerard D Schellenberg Kimmo J Hatanpaa Myron F Weiner Charles L White William S Brooks Glenda M Halliday Jillian J Kril Marla Gearing Thomas G Beach Neill R Graff-Radford Dennis W Dickson Rosa Rademakers Bradley F Boeve Stuart M Pickering-Brown Julie Snowden John C van Swieten Peter Heutink Harro Seelaar Jill R Murrell Bernardino Ghetti Salvatore Spina Jordan Grafman Jeffrey A Kaye Randall L Woltjer Marsel Mesulam Eileen Bigio Albert Lladó Bruce L Miller Ainhoa Alzualde Fermin Moreno Jonathan D Rohrer Ian R A Mackenzie Howard H Feldman Ronald L Hamilton Marc Cruts Sebastiaan Engelborghs Peter P De Deyn Christine Van Broeckhoven Thomas D Bird Nigel J Cairns Allison Goate Matthew P Frosch Peter F Riederer Nenad Bogdanovic Virginia M Y Lee John Q Trojanowski Vivianna M Van Deerlin

OBJECTIVE To assess the relative frequency of unique mutations and their associated characteristics in 97 individuals with mutations in progranulin (GRN), an important cause of frontotemporal lobar degeneration (FTLD). PARTICIPANTS AND DESIGN A 46-site International Frontotemporal Lobar Degeneration Collaboration was formed to collect cases of FTLD with TAR DNA-binding protein of 43-kDa (TDP-...

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Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase.

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2011

Anja Capell Sabine Liebscher Katrin Fellerer Nathalie Brouwers Michael Willem Sven Lammich Ilse Gijselinck Tobias Bittner Aaron M Carlson Florenz Sasse Brigitte Kunze Heinrich Steinmetz Rolf Jansen Dorothee Dormann Kristel Sleegers Marc Cruts Jochen Herms Christine Van Broeckhoven Christian Haass

Numerous loss-of-function mutations in the progranulin (GRN) gene cause frontotemporal lobar degeneration with ubiquitin and TAR-DNA binding protein 43-positive inclusions by reduced production and secretion of GRN. Consistent with the observation that GRN has neurotrophic properties, pharmacological stimulation of GRN production is a promising approach to rescue GRN haploinsufficiency and prev...

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