In vitro studies on cancer cell lines still constitutes a major part of cancer research. It is very important that the researchers consider the importance of basic conditions of working with different cell lines. To the best of authors knowledge, this study is the first one to report the effect of seeding density on the growth curve of three human cancer cell lines. These cell lines include hum...

The following description of the package grofit was also published as Kahm et al. (2010). The grofit package was developed to fit many growth curves obtained under different conditions in order to derive a conclusive dose-response curve, for instance for a compound that potentially affects growth. grofit fits data to different parametric models and in addition provides a model free spline metho...

We describe methods to fit structured latent growth curves to data from MZ and DZ twins. The well-known Gompertz, logistic and exponential curves may be written as a function of three components - asymptote, initial value, and rate of change. These components are allowed to vary and covary within individuals in a structured latent growth model. Such models are highly economical, requiring a sma...

Comparison of forest growth curves has led many to the conclusion that there is a similarity between forest stands growing in different conditions. Thus, in the beginning of the past century Alexander Turin, a wellknown forest scientist, made an important empirical generalization: “The normal pine stands with equal heights at a certain age had the same growth in the past and will have the same ...

The article by Lindell et al 1 documenting the growth curves of 18 lung cancers that was recently published in CHEST patient, the decisions to initiate and terminate SUP should be considered carefully and individually. We wholly agree with Dr Porath that both initiation of SUP and its continuation beyond the ICU and the hospital require meticulous attention in order to minimize individual and p...

We adapt the interactive spline model of Wahba to growth curves with covariates. The smoothing spline formulation permits a nonparametric representation of the growth curves. In the limit when the discretization error is small relative to the estimation error, the resulting growth curve estimates often depend only weakly on the number and locations of the knots. The smoothness parameter is dete...

The multilevel model of change and the latent growth model are flexible means to describe all sorts of population heterogeneity with respect to growth and development, including the presence of sub-populations. The growth mixture model is a natural extension of these models. It comes at hand when information about sub-populations is missing and researchers nevertheless want to retrieve developm...

A general branching process model is proposed to describe the shortening of telomeres in eukaryotic chromosomes. The model is flexible and incorporates many special cases to be found in the literature. In particular, we show how telomere shortening can give rise to sigmoidal growth curves, an idea first expressed by Portugal et al. [A computational model for telomere-dependent cell-replicative ...

The problem of comparing a sequence of independent experiments divided into several groups with a control is discussed under the logistic growth-curve models. We propose a method for constructing multiple testing procedures using the closed testing procedures and the random-effect model for summarizing estimated values of parameters.

Examination of growth curves, which reflect changes in quantity of the products of viral multiplication over a period of time, offers a promising approach to further understanding of the phenomenon of viral reproduction. Henle et al.' have described growth curves based upon the titers of pooled allantoic fluids from groups of eggs sacrificed at various intervals of time after inoculation of inf...