A substance immunochemically cross-reactive with insulin (SICRI) appears in melanoma B16 growing in diabetic and nondiabetic C57BL/6 mice. Progression of tumor size is paralleled by the increase of SICRI levels in the serum of both diabetic and nondiabetic animals; this increase correlates with a decreased concentration of circulating glucose and an elevated concentration of growth hormone in b...

Growth hormone, acting through its receptor (GHR), plays an important role in carbohydrate metabolism and in promoting postnatal growth. GHR gene-deficient (GHR(-/-)) mice exhibit severe growth retardation and proportionate dwarfism. To assess the physiological relevance of growth hormone actions, GHR(-/-) mice were used to investigate their phenotype in glucose metabolism and pancreatic islet ...

introduction: acute lymphoblastic leukemia (all) and non hodgkin’s lymphoma(nhl) are the most common cancers in childhood and  adolescence. most children with all and nhl have long term survival (>80%). endocrinopathy is a common complication in pediatric cancers following the treatment (20-50% prevalence), in addition, cytotoxic chemotherapy and radiotherapy can influence side effect on growth...

Growth factors regulated by specific macronutrients have been shown to promote aging and accelerate mortality in the majority of the organisms studied. In particular, the enzymes activated by growth hormone, insulin, and insulin-like growth factor-1 in mammals and their orthologs in simple model organisms represent perhaps the best-understood proteins involved in the aging process. Dietary rest...

A substance immunochemically cross-reactive with insulin (SICRI) appears in melanoma B16 growing in diabetic and nondiabetic CS7BL/6 mice. Progression of tumor size is paralleled by the increase of SICRI levels in the serum of both diabetic and nondiabetic animals; this increase correlates with a decreased concentration of circulating glucose and an elevated concentration of growth hormone in b...

background: polycystic ovarian syndrome (pcos) is a common disease among women in fertility ages and cause severe insulin resistance. hyperhomocysteinaemia is said to be among the features of pcos that could influence its outcome. objective: this study aimed to investigate whether hyperhomocysteinaemia exists in pcos and if it is related to insulin resistance in the affected patients. materials...

A B S T R A CT To study the individual effects of glucagon and growth hormone on human carbohydrate and lipid metabolism, endogenous secretion of both hormones was simultaneously suppressed with somatostatin and physiologic circulating levels of one or the other hormone were reproduced by exogenous infusion. The interaction of these hormones with insulin was evaluated by performing these studie...

obesity is a chronic disease that shows the most serious global health problems .it relates to the body fat .obesity is caused by an imbalance between energy intake and expenditure, this balance is regulated by genetic and environmental interactions. obesity, which is a risk factor for chronic diseases, has become epidemic in the developed countries. resistance to leptin hormone is one of the m...

Theodoridis, C. G., Chance, G. W., Brown G. A., and Williams, J. W. (1970), Archives of Disease in Childhood, 45, 70. Plasma insulin and growth hormone levels in untreated diabetic children. Blood glucose, plasma insulin, and growth hormone were measured in 28 untreated diabetic children, and the results were compared with those obtained from a control group. Though 2 of the 28 diabetic childre...

We have measured protein kinetics in the scalded skin and normal muscle in anesthetized rabbits. On the 7th day after ear scald,l-[ ring-13C6]phenylalanine was infused as a tracer, and the ear and hindlimb were used as arteriovenous units to reflect skin and muscle protein kinetics. Insulin was infused at 0.6 or 2.3-3.4 mU ⋅ kg-1 ⋅ min-1in the low-dose and high-dose insulin groups. In the growt...