Objective(s): Infection with tuberculosis (TB) is regarded as a major health issue. Due to the emergence of antibiotic resistance during TB treatment, prevention via vaccination is one of the most effective ways of controlling the infection. DNA vaccines are developed at a greater pace due to their ability in generating a long-lasting immune response, higher safety com...

BACKGROUND: The mode of action Bacillus Calmette-Guérin (BCG) in the treatment patients with non-muscle invasive bladder cancer (NMIBC) is incompletely understood, but recent studies support an association between BCG-induced trained immunity circulating monocytes and disease-free survival. OBJECTIVE: We compared epigenetic profiles from NMIBC early disease recurrence those recurrence-free pati...

BACKGROUND There is an urgent need for an improved tuberculosis vaccine. The lack of a validated correlate of protection slows progress in achieving this goal. A human mycobacterial challenge model, using bacille Calmette-Guérin (BCG) as a surrogate for a Mycobacterium tuberculosis challenge, would facilitate vaccine selection for field efficacy testing. Optimization of this model is required. ...

Bacille Calmette-Guérin (BCG) induces potent Th1 responses with the help of interleukin (IL)-10 and IL-12 released from dendritic cells (DCs), and suppresses Th2- associated allergic reactions. However, there are still some controversies on therapeutic effects of BCG in asthmatics. This study investigated whether BCG administration to DCs suppresses IL-5 production from T cells in atopic asthma...

BCG (Bacillus Calmette-Guérin) immunotherapy is a method which an emerging form of cancer treatment. attaches to the bladder wall and stimulates immune response destroy cells. Complications therapy are due reactivated infection or hypersensitivity reaction thus may be treated with antimycobacterial agents, corticosteroids, both. instillations should also stopped if complications occur during tr...

Abstract Objective To investigate the genetic prognostic factors for recurrence of non-muscle invasive bladder cancer. Materials and methods The patients underwent transurethral resection tumor received bacillus Calmette–Guérin (BCG) or epirubicin. Next-generation sequencing was performed alterations genes, pathways, mutation burden were recorded. Associations between these clinicopathological ...

Pyroptosis is a host immune strategy to defend against Mycobacterium tuberculosis (Mtb) infection. S100A4, calcium-binding protein that plays an important role in promoting cancer progression as well the pathophysiological development of various non-tumor diseases, has not been explored Mtb-infected hosts. In this study, transcriptome analysis peripheral blood patients with pulmonary (PTB) reve...

  Background: Tuberculosis is an essential problem for healthcare systems especially in developing countries . All newborns are given Bacillus Calmette-Guérin (BCG) vaccine in Iran which is prepared from live bovine tuberculosis bacillus, and is given to protect against tuberculosis. Osteomyelitis secondary to BCG vaccination is rare and usually involves epiphysis of long tubular bones. Methods...

Intralesional Mycobacterium bovis bacillus Calmette-Guérin (BCG) has long been a relatively inexpensive therapy for inoperable cutaneous metastatic melanoma (CMM), although intralesional BCG skin mechanisms remain understudied. We analyzed intralesional BCG-treated CMM lesions combined with in vitro studies to further investigate BCG-altered pathways. Since macrophages play a pivotal role again...