The STAT transcription factors, usually referred to as "latent cytoplasmic proteins," have experienced a fundamental reevaluation of their dynamic properties. This review focuses on recent studies that have identified continuous transport factor-independent nucleocytoplasmic cycling of STAT1, STAT3, and STAT5 as a basic principle of cytokine signaling. In addition, molecular mechanisms that mod...

BACKGROUND Conflict of interest (COI) is an important potential source of bias in the development of clinical practice guidelines (CPGs) and high rates of COI among guideline authors have been reported in the past. Our objective was to report current rates of disclosure and specific author COI across a broad range of CPGs and to examine whether CPG characteristics were associated with the prese...

OBJECTIVE To investigate the impact of nutritional support on clinical outcomes in patients at nutritional risk who receive nutritional support that meets guideline standards and those who do not. METHODS This prospective cohort study enrolled hospitalized patients from the Second Affiliated Hospital of Kunming Medical University from February 2010 to June 2012. The research protocols were ap...

OBJECTIVES To evaluate the impact of selective fluconazole prophylaxis on incidence of invasive fungal infection and emergence of fluconazole resistance in neonatal intensive care. DESIGN Retrospective study of very low birthweight (VLBW) babies (<1500 g birth weight) admitted to a neonatal intensive care unit (NICU) in the period 1 year before and after the implementation of an antifungal pr...

OBJECTIVE The aim of the paper is to investigate the association between physicians' adherence to a pharmacotherapy guideline and continuity of care for patients with depressive and/or anxiety disorders in a collaborative care program. METHODS This retrospective observational study was conducted using medical records of subjects suffering from depression and/or anxiety disorder visited by 26 ...

conclusions an insufficient formal education in cpr was registered for all groups, reflecting the lack of familiarity with new cpr methods. a team education, involving doctors and nurses may improve familiarity with cpr and patient outcomes. results the only difference between groups was regarding the male and female ratio, with more male surgeons (45, 55, and 11, p < 0.001). all doctors consid...

introduction: although significant development in the field of medicine is achieved, sepsis is still a major issue threatening humans’ lives. this study was aimed to audit the management of severe sepsis and septic shock patients in emergency department (ed) according to the present standard guidelines. method: this is a prospective audit on approaching adult septic patients who were admitted t...

background: back pain is a common patients’ complaint, and its etiology is important because of different potential treatment approaches (based on causes). for a better diagnosis, magnetic resonance imaging (mri) is widely used in clinical settings that may result in inappropriate requests. this study aims to evaluate the appropriateness of the lumbosacral mri requests in patients with back pai...

epidemics of methanol poisoning happen across the globe. there are prognostic factors associated with morbidity or mortality from methanol poisoning. recently we have compared retrospective observational case series of methanol-poisoned patients from norway (1979 and 2002-2005), estonia (2001) and tunisia (2003/2004), and patients from two different centers in iran (teheran 2004-2009 and mashha...

Background Integrating guideline knowledge with clinical workflow plays a critical role in effective guideline implementation strategies. Eight information management services promote integration of computerized systems into clinical workflow—recommendation, documentation, explanation, presentation, registration, communication, calculation and aggregation. The Guideline Elements Model (GEM) use...