hantzsch 1 ,4- dihy&opyridines; are rapidly oxidized to the corresponding pyridine derivatives using zinc chlorochromate nonahydrate [zn(c1cro ) .9h o] in dichloromethane at room temperature. in addition to aromatization, no loss of the 4- substituent is observed

A new series of 2-hydrazone-thiazoline-4-ones 3a-d and 2-hydrazone-5arylidene-thiazoline-4-ones 4a-h, 5a-f and 6a-b were synthesized starting from various thiosemicarbazones by the Hantzsch condensation with chloroacetic acid. The newly synthesized compounds were screened for their antimicrobial activity against 4 strains of bacteria: Staphylococcus aureus (ATCC 29213), Bacillus subtilis (ATCC ...

A general process for the high-yielding synthesis of substituted chiral and achiral α-substituted acrylates was achieved through the sequential one-pot combination of a metal-free reductive coupling reaction followed by an Eschenmoser methylenation. The proline catalyzed reaction of Meldrum's acid, aldehydes and Hantzsch ester followed by methylenation was successful with Eschenmoser's salt in ...

New and known arylidene-hydrazinyl-thiazole derivatives have been synthesized by a convenient Hantzsch condensation. All compounds were evaluated for their in vitro cytotoxicity on two carcinoma cell lines, MDA-MB231 and HeLa. Significant antiproliferative activity for 2-(2-benzyliden-hydrazinyl)-4-methylthiazole on both MDA-MB-231 (IC50: 3.92 µg/mL) and HeLa (IC50: 11.4 µg/mL) cell lines, and ...

This work concerns the synthesis of poly(pyrazolopyridine)s via a three-component Hantzsch reaction. The first part this study was intended to determine adequate experimental conditions for an analytically pure pyrazolopyridine heterocycle model compound in quantitative yield, which can be further used polymer synthesis. For purpose, effect different parameters (solvent, temperature, additive) ...

A three component reductive coupling reaction of a (hetero)aromatic amine, a (hetero)aromatic aldehyde and an electron deficient olefin catalysed by eosin Y under green LED light irradiation, for the direct generation of γ-amino acid derivatives, is described. This new umpolung synthesis of amines, which exploits the high nucleophilicity of a putative α-amino radical intermediate, generated via...

We have developed a direct amine/acid-catalyzed stereoselective hydrogenation of a variety of Wieland-Miescher (W-M) ketones, Hajos-Parrish (H-P) ketones and their analogs with organic hydrides (Hantzsch esters) as the hydrogen source. This astonishingly simple and biomimetic approach was used to construct highly functionalized chiral bicyclo[4.4.0]decane-1,6-diones in a diastereoselective fash...

This work proposes a flow system suitable for the rapid screening of formaldehyde contaminated in food. The system is based on the concept of a flow analyzer with a Hantzsch reaction. An operating procedure was developed for multiple tasking and high sample throughput. This resulted in a significant sample throughput of 51 samples h(-1). Under the optimized conditions, linear calibration from 1...