Studies concerning the antigenicity of thyroglobulin fragments allow the characterization of the epitopes but do not consider the role of heavier antigenic fragments that could result in vivo from the action of endoproteases. Here we assess the relative importance of the fragments obtained from thyroglobulin by limited proteolysis with trypsin and compare by immunoblotting their reactivity to s...

Thyroiditis is an inflammation of the thyroid gland that may be painful and tender when caused by infection, radiation, or trauma, or painless when caused by autoimmune conditions, medications, or an idiopathic fibrotic process. The most common forms are Hashimoto's disease, subacute granulomatous thyroiditis, postpartum thyroiditis, subacute lymphocytic thyroiditis, and drug-induced thyroiditi...

www.aafp.org/afp AMERICAN FAMILY PHYSICIAN 1717 ation of the thyroid subsequent to Graves’ disease and surgical removal of the thyroid gland. Long-term thyroid dysfunction after subacute granulomatous thyroiditis (de Quervain’s thyroiditis) or subacute lymphocytic thyroiditis (silent or painless thyroiditis) is fairly rare. Full thyroid function is regained in 90 percent of patients with these ...

Background: Struma ovarii (SO) is a rare phenomenon. In addition, it can be identified from the histological assessment and may show the characteristics of Hashimoto’s thyroiditis in rare cases. In several cases, malignant stroma ovarii is found to produce hyperthyroidism while very few cases are reported with Hashimoto’s thyroiditis. The present study reported SO co-incident with Hashimoto’s t...

Background: Thyroiditis is the inflammation of the thyroid gland. Hashimoto’s thyroiditis (HT) is the most common cause of hypothyroidism in those areas of the world where iodine levels are sufficient. Hashimoto’s thyroiditis, a synonym of chronic lymphocytic thyroiditis or autoimmune thyroiditis, is the second most common thyroid lesion diagnosed on FNAC after goiter. FNAC plays a significant ...

Background Inflammation of the orbital connective tissue, extraocular muscles and upper eyelids occurs in about 40% of patients with Graves hyperthyroidism [Graves Ophthalmopathy (GO)] while mild eye signs including upper eyelid retraction are found in as many as 25% of patients with Hashimoto thyroiditis and, occasionally, transient thyroiditis. Some workers have proposed a relationship betwee...

UNLABELLED This study aimed to determine the reference range of 24-h radioiodine uptake in euthyroid Jordanians, as well as the reference ranges for patients with diffuse and nodular hyperthyroidism. In addition, radioiodine uptake ranges were determined for those patients with Hashimoto's thyroiditis and early-phase subacute thyroiditis. METHODS The medical records of 285 Jordanian patients ...

The most common causes of thyrotoxicosis in Japan are silent thyroiditis and Graves’ disease. For patients with thyrotoxicosis present in early pregnancy, both gestational thyrotoxicosis and undiagnosed Graves’ disease must be considered. Silent thyroiditis is a rare condition during pregnancy. Postpartum thyroiditis is a variant of silent thyroiditis that occurs in the postpartum period, a few...

This case report reviews the rare condition of Riedel's thyroiditis via a patient case. The report highlights the difficulties that one may encounter when managing such a case in regards to patient symptoms, side effects of medications and the relapsing nature of the condition. The case report also highlights novel treatment in the treatment of Riedel's thyroiditis, rituximab, how this works an...

INTRODUCTION Subacute thyroiditis is a self-limited, inflammatory viral thyroid disease which presents with neck pain, usually accompanied by systemic symptoms. On the other hand, thyroid storm is a clinical condition of severe sudden hyperthyroidism accompanied by physiologic de-compensation. We presented a 29-year-old male with features of subacute thyroiditis and thyroid storm who is the thi...