CONTEXT Congenital hyperinsulinism (HI) is a common cause of hypoglycemia in infancy. The medical treatment of diazoxide-unresponsive HI is based on a somatostatin analogue. OBJECTIVE This study aims at replacing three daily s.c. octreotide (Sandostatin, Novartis) injections by a single and monthly i.m. injection of long-acting release (LAR) octreotide (Sandostatin LP, Novartis) in HI patient...

OBJECTIVE To evaluate the endothelial functions before and after glycemic control in type II diabetes mellitus. MATERIAL AND METHODS It was an open, randomized and comparative study on 30 patients of type 2 diabetes mellitus. The study was of 12 weeks spread over 5 visits. The initial visit (visit 1) is for screening of patients. Other visits (visits 2 to 5) constituted the follow up of patie...

OBJECTIVE Our aim was to detect whether there is any change in apparent diffusion coefficients (ADC) levels in different sites of the brain, particularly in areas associated with the vision, in diabetic patients with retinopathy by measuring diffusion-weighted imaging (DWI). MATERIALS AND METHODS Conventional magnetic resonance imaging (MRI) and DWI of the brain were obtained from 45 diabetic...

OBJECTIVE Previous studies have shown that endothelial dysfunction, an early sign of atherosclerosis, occurs in animal models of diabetes mellitus and in resistance vessels of patients with insulin-dependent diabetes. In the present study we examined whether young patients with insulin-dependent diabetes without microalbuminuria present abnormal endothelial function of large peripheral arteries...

Maternal haemoglobin Al, (HbA,,) values were measured before the end of the 15th week of gestation in 142 pregnancies in women with insulin dependent diabetes. In pregnancies complicated by fetal malformations (n=: 17) the mean initial HbAl, value was 9 5 (SD 1 8)% of the total haemoglobin concentration, which was significantly (p <0 001) higher than in pregnancies without malformations (8 0 (S...

OBJECTIVES To estimate the prevalence of non-alcoholic fatty liver disease (NAFLD) by ultrasonography, and to correlate NAFLD with coronary artery disease (CAD) and coronary risk factors in a group of Indian type 2 diabetics. METHODS Consecutive patients of type 2 diabetes were recruited. History and physical examination were recorded. Laboratory investigations included fasting and 2-hour pos...

BACKGROUND Among diabetic patients autonomic neuropathy (AN) is one of the most frequent complications. This affects peripheral nervous system and thus results into erectile dysfunction (ED). The main objectives of the study were to determine the frequency of autonomic neuropathy (AN) in diabetic patients with ED and to find out the associated risk factors. METHODS In this descriptive case se...

In order to examine the relationship between anti-insulin antibodies (AIA) caused by extrinsic human insulin and albuminuria or proteinuria, 53 human insulin-treated type 2 diabetics were divided into two groups: (AIA(+) group) 27 patients with a titer of AIA greater than 7.6% and (AIA(-) group) 26 patients with a titer of AIA less than 7.5%. Although no significant difference was found between...

UNLABELLED Type 1 diabetes is a metabolic diseases characterized by hyperglycemia, results from the destruction of insulin-producing pancreatic beta cells. Diabetes management usually by insulin, dietary and physical activity. AIM Assess the relationship between physical activity and glycemic control in type 1 diabetes subjects. METHODS The literature search conducted in Pubmed and ScienceD...

Fermented ginseng (FG) is an ethanol extract of ginseng radix processed with β-galactosidase. It was hypothesized that FG may exert anti-hyperlipidemic and anti-diabetic activities through modulating AMP-activated protein kinase (AMPK) in HepG2 human hepatoma cells. In this study, we showed that AMPK phosphorylation was stimulated by FG. These effects were abolished by pretreatment with an AMPK...