High-density monolayers (HDMs) of single-strand (ss) DNA are important nanoscale platforms for the fabrication of sensors and for mechanistic studies of enzymes on surfaces. Such systems can be used, for example, to monitor gene expression, and for the construction of more complex nanodevices via selective hybridization with the complementary oligos dissolved in solution. In this framework, con...

BACKGROUND The murine polyp model was developed previously using ovalbumin and Staphylococcus aureus enterotoxin B (SEB). Here, we established a model mimicking key aspects of chronic eosinophilic rhinosinusitis with nasal polyps using the house dust mite (HDM), a clinically relevant aeroallergen, co-administered with SEB. We assessed the inflammatory response and formation of nasal polypoid le...

BACKGROUND Exposure to allergens plays a role in the development of bronchial hyperresponsiveness and in the chronic inflammatory response seen in asthmatic patients. House dust mites (HDMs) are an important source of allergen. Reduction of these allergens might lead to better lung function and reduction of asthma symptoms. OBJECTIVE The effect of HDM-impermeable covers on HDM allergen levels...

We present in this paper an overview of the Hidden Dynamic Model (HDM) paradigm, exemplifying parametric construction of structure-based speech models that can be used for recognition purposes. We explore a general class of the HDM that uses recursive, autoregression functions to represent the hidden speech dynamics, and uses neural networks to represent the functional relationship between the ...

BACKGROUND Common antigens between intestinal parasites and environmental allergens may play a role in the modulation of allergic immune responses. There is a growing interest in investigating cross-reactivity between common helminths and dust mites affecting humans, particularly in the tropics. OBJECTIVE This study examined the cross-reactivity between the human roundworm Ascaris lumbricoide...

There is an unmet need for effective new and innovative treatments for asthma. It is becoming increasingly evident that bacterial stimulation can have beneficial effects at attenuating allergic airway disease through immune modulation. Our aim was to test the ability of a novel inactivated microbe-derived therapeutic based on Klebsiella (KB) in a model of allergic airway disease in mice. BALB/c...

An adaptive approach to using reduced-order models as surrogates in PDE-constrained optimization is introduced that breaks the traditional offline-online framework of model order reduction. A sequence of optimization problems constrained by a given Reduced-Order Model (ROM) is defined with the goal of converging to the solution of a given PDE-constrained optimization problem. For each reduced o...

BACKGROUND Asthma is a common chronic disease worldwide and Ascaris lumbricoides infection (ascariasis) is frequent in tropical regions. However, the effect of ascariasis on asthma severity has not been sufficiently explored. We sought to evaluate the influence of the IgE immune response to Ascaris extract and purified house dust mites (HDM) and Ascaris allergens on indicators of asthma severit...

BACKGROUND Shrimp and house dust mite (HDM) allergies are common in Canadians. Often, both of these allergies occur in the same patient. This may be due to homology of tropomyosin or other potentially shared proteins. The aim of our study was to assess the frequency of house dust mite sensitization in a shrimp allergic Canadian population. METHODS We undertook a retrospective chart review of ...

study at the 4-year follow-up. Thirty-five percent had been diagnosed with asthma by pediatric allergists and 10.7% had episodes of wheezing, but were not diagnosed with asthma. Eighty-five percent of patients had specific IgE levels against at least 1 of the following 5 food allergens (egg white, milk, wheat, soybean, and rice). HDM-specific IgE increased from 11% at registration to 59% at the...