introduction: a rare case of basaloid squamous cell carcinoma (bscc) of the larynx, which has not been previously reported, is described. case report: a 60-year-old man was presented to the otolaryngology department with progressive dyspnoea and dysphagia to solids for over a period of 1 week. direct laryngoscopy revealed a tumour at the laryngeal aspect of the epiglottis, which prolapsed into ...

Introduction: The presence of HER-2 has been shown to be a prognostic factor in many kinds of cancers, but its role in head and neck squamous cell carcinoma (HNSCC) is not still defined. The purpose of the current study is to investigate the role of HER-2 in HNSCC and its correlation with various clinicopathologic parameters.   Materials and Methods: Peripheral blood samples were obtained ...

A subset of head and neck squamous cell carcinomas are caused by the human papillomavirus (HPV). This HPV-related form of head and neck squamous cell carcinoma (HPV-HNSCC) has captured the attention of the oncology community for its rising incidence, its link to non-traditional risk factors, and its divergent clinical behavior. To diagnose this special form of head and neck squamous cell carcin...

1. Saini R, Sharma N, Pandey K, et al. Multiple skin cancers in a single patient: Multiple pigmented Bowen's disease, giant basal cell carcinoma, squamous cell carcinoma. J Cancer Res Ther 2015;11:669. 2. Veness MJ. Advanced non melanoma skin cancers of the head and neck: an overview on management. Cancer Forum 2006;30:195-201. 3. Ch'ng S, Maitra A, Lea R, et al. Parotid metastasis: an independ...

Spindle cell carcinoma (SpCC) is an unusual variant of squamous (S.C.C.) the head and neck region. It a rare biphasic neoplasm.  SpCC morphological S.C.C.  characterized by presence both carcinomatous as well sarcomatous component accounts for 2 to 3% all S.C.C.s. Seven years ago, W.H.O. classification has placed this tumor under malignant epithelial tumors called it SpCC. The histoge...

BACKGROUND Constitutive activation of nuclear factor κB (NF-κB) is associated with poor prognosis. Irinotecan demonstrates single-agent activity in head and neck cancer but activates NF-κB, promoting cell survival and resistance. Bortezomib is a proteasome inhibitor that inactivates NF-κB. PATIENTS AND METHODS We performed a randomized phase II trial of bortezomib on days 1, 4, 8, and 11 and ...

BACKGROUND Oncogenic human papillomaviruses (HPVs), especially HPV type 16 (HPV-16), cause anogenital epithelial cancers and are suspected of causing epithelial cancers of the head and neck. METHODS To examine the relation between head and neck cancers and HPVs, we performed a nested case-control study within a joint Nordic cohort in which serum samples were collected from almost 900,000 subj...

The multidisciplinary approach to treating squamous cell carcinoma of the head and neck is complex and evolving. Chemotherapy is increasingly being incorporated into the treatment of squamous cell carcinoma of the head and neck. Previously, radiotherapy following surgery was the standard approach to the treatment of loco regionally advanced resectable disease. Data from randomized trials have c...