The current status and needs of thermal biology and physiology as related to clinical hyperthermia are summarized. Emphasis is placed on heat-induced modification of blood flow and microenvironment in tissues, on the biological effects of heat and X-rays, and on the relationship between drug resistance, heat resistance, and thermotolerance in thermochemotherapy. Results from recent studies inve...

a pressure-based coupled heat and mass transfer model was used to simulate temperature and soil suction in a drying process within a clay soil column. closed form functions were used for all parameters needed in the governing equations. model predictions were compared with experimental data using the mean relative percentage deviation method. thermocouples and mini-gypsum blocks were used t...

Heat denaturation studies were carried out and revealed hidden genic variants with the same net charge at the Octanol dehydrogenase-1 locus in Drosophila pseudoobscura. Studies of several genetic crosses between strains with different heat-sensitivity alleles showed that the F(1) retained more in vitro enzyme activity after being heat-treated for a specified amount of time at a given temperatur...

BACKGROUND This article describes the methods and results of the early part (experimental pain tests and postoperative analgesia) of a study that assesses genetic and other factors related to acute pain and persistent pain after treatment of breast cancer in a prospective cohort of 1,000 women. METHODS One thousand consenting patients were recruited to the study. Before surgery (breast resect...

The tyrosine kinase receptor c-Kit is critically involved in the modulation of nociceptive sensitivity in mice. Ablation of the c-Kit gene results in hyposensitivity to thermal pain, whereas activation of c-Kit produces hypersensitivity to noxious heat, without altering sensitivity to innocuous mechanical stimuli. In this study, we investigated the role of c-Kit signaling in human pain percepti...

We evaluated the effects of the menstrual cycle and physical training on heat loss (sweating and cutaneous vasodilation) responses during moderate exercise in a temperate environment. Ten untrained (group U) and seven endurance-trained (group T) women (maximal O2 uptake of 36.7+/-1.1 vs. 49.4+/-1.7 ml.kg-1.min-1, respectively; P<0.05) performed a cycling exercise at 50% maximal O2 uptake for 30...

: Heatwave events occur more frequently, accompanied by a significant increase in the ambient concentration of fine particulate matter (PM2.5). Epidemiological and experimental studies have suggested that heat stress or PM2.5 exposure would impair glucose homeostasis insulin sensitivity. To explore joint effects on metabolism hepatic pathway. C57BL/6 mice were randomly divided into filtered air...