Differences in nontreatment-related covariates ("prognostic factors") often account for differences between treatments in clinical cancer trials. This is true even in randomized trials in which the number of patients randomized is less than 200. Hence analysis of prognostic factors is crucial in historically controlled and small randomized trials. However, it is known that factors found prognos...

CONTEXT Dysplastic changes are well documented in myelodysplastic syndromes (MDS). However, they are also observed in non-MDS hematological conditions. AIMS To evaluate the megakaryocytic alterations in the bone marrow aspirations in cases of non-MDS related thrombocytopenia. SETTING AND DESIGN A prospective study of 144 bone marrow aspirates was conducted in the department of pathology, Ka...

Liver involvement is often observed in several hematological disorders, resulting in abnormal liver function tests, abnormalities in liver imaging studies, or clinical symptoms presenting with hepatic manifestations. In hemolytic anemia, jaundice and hepatosplenomegaly are often seen mimicking liver diseases. In hematologic malignancies, malignant cells often infiltrate the liver and may demons...

Background: Metastatic colorectal cancer (mCRC) is often treated with a mFOLFOX6 regimen. The 5-fluorouracil (5-FU) bolus omitted from the regimen to reduce risk of hematological adverse events (AEs) in patients poor performance status. We aimed investigate incidence AEs Asian mCRC who were and without 5-FU dosing. Methods: This retrospective chart review was conducted at King Chulalongkorn Mem...

3 About tetrachloroethylene 7 I Study materials I-1 Study sample lots, etc .. 14 I-2 Identity, stability of study sample 14 I -2-1. Identity 14 I-2-2 Stability 14 I-3 Laboratory animals 14 II Study methods IIL Administration II-1-1 Administration route, administration method, and administration period 15 II-1-2. Administration concentration and reason for establishing the same 15 II-1-3 Method ...

Interferons (IFNs) are peptides with antitumoral action, widely used for the treatment of many diseases of oncologic origin. New evidences on the effect of a combination of IFN a2b and IFN g led to the formulation, CIGB 128, containing both IFNs. A variant, CIGB 128-A, was generated through excipient optimization, to reduce the number of administrations and the undesirable effects of the produc...

Objectives: The hematological changes usually associated with malaria are well known. This study was conducted to estimate and compare the predominance & severity of hematological changes in common types of malaria. Methodology: This observational study included 400 suspected malarial patients attended in Out Patient Department (OPD) and In Patient Department (IPD) of NKP Salve Institute of Med...

Chagasin may be considered a potential plant-incorporated protectant (PIP) protein due to its deleterious effects on insect pests. However, extensive safety studies with PIP's are necessary before introducing them into the target plant. Thus, a short-term feeding trial in rats with high doses of r-chagasin was conducted to provide evidences about its safety. Three test diets containing casein +...

The purpose of the present study was to elucidate the influence of intermittent hypobaric hypoxia at rest on endurance performance and cardiorespiratory and hematological adaptations in trained endurance athletes. Twelve trained male endurance runners were assigned to either a hypoxic group (n = 6) or a control group (n = 6). The subjects in the hypoxic group were exposed to a simulated altitud...