The World Health Organization (WHO) classification of hematopoietic neoplasms, published in 2001, included the new category of “Myelodysplastic/ Myeloproliferative Diseases,” intended to accommodate those myeloid neoplasms that simultaneously showed features of chronic myeloproliferative disorders and myelodysplastic syndromes. Typically, myelodysplastic syndromes (MDS) are clonal neoplastic di...

Due to the neoplastic nature of myelodysplastic syndromes (MDS), they have been renamed as neoplasms in World Health Organization (WHO) 2022 classification. These are heterogeneous groups myeloid disorders characterized by dysplasia bone marrow cells, ineffective hematopoiesis, increased apoptosis, peripheral blood cytopenia, and risk progression acute leukemia (AML). The recent progress unders...

Multiple circular or oval pulmonary densities on chest roentgenogram most commonly represent neoplastic metastases. This radiographic picture may also be seen in other tumors (lymphoma, myeloma), infectious diseases (especially tuberculosis and fungal chest diseases), immunologic disorders (Wegener’s granulomatosis and rheumatoid lung), mucoid impaction, pneumoconiosis, A-V fistulae, multiple b...

Enormous numbers of adult blood cells are constantly regenerated throughout life from hematopoietic stem cells through a series of progenitor stages. Accessibility, robust functional assays, well-established prospective isolation, and successful clinical application made hematopoiesis the classical mammalian stem cell system. Most of the basic concepts of stem cell biology have been defined in ...

Background Histiocytoses are rare clonal disorders characterized by the proliferation and accumulation of CD68 + histiocytes in tissues [1] . During histiocytosis, circulating monocytes arising from bone marrow progenitors carry most MAP-kinase gene mutations, but only “classical” can differentiate into tissue [2] However, little is known about monocyte subset distribution histiocytoses [3] the...

Essential thrombocythemia (ET) and polycythemia vera (PV) are chronic myeloproliferative disorders that share the involvement of a multipotent progenitor cell and dominance of the transformed clone over normal hematopoiesis. On the other hand, the heterogeneity of these diseases with respect to clonal development from a common progenitor has been well established. To identify useful prognostic ...

Myelodysplastic syndromes (MDS) are clonal disorders of the multipotent hematopoietic stem cell characterized by ineffective hematopoiesis and associated with marrow hypercellularity, increased intramedullary cell death and peripheral cytopenias of varying severity. Patients with myelodysplasia have a propensity (20% to 30% of cases) to undergo transformation into acute myeloid leukemia (AML), ...

Organisation of RNAs into functional subgroups that are translated in response to extrinsic and intrinsic factors underlines a relatively unexplored gene expression modulation that drives cell fate in the same manner as regulation of the transcriptome by transcription factors. Recent studies on the molecular mechanisms of inflammatory responses and haematological disorders indicate clearly that...

MRP8 and MRP14 are two S100-like calcium-binding proteins of unknown function, associated with numbers of human inflammatory disorders. Both molecules have been described as L1 complex, cystic fibrosis antigen, or p8 and p14. We report here the cloning of mouse MRP8 and MRP14 and their pattern of expression during hematopoiesis. Mouse MRP8 and MRP14 proteins share 59% identity with their human ...