نتایج جستجو برای: heme oxygenase

تعداد نتایج: 23033  

Journal: :The Journal of biological chemistry 1998
K Ishikawa K M Matera H Zhou H Fujii M Sato T Yoshimura M Ikeda-Saito T Yoshida

A truncated, soluble, and enzymatically active form of human heme oxygenase-2 (DeltaHHO2) was expressed in Escherichia coli. To identify the axial heme ligand of HO-2, His-45 to Ala (DeltaH45A) and His-152 to Ala (DeltaH152A) mutants have been prepared using this expression system. DeltaH45A could form a 1:1 complex with hemin but was completely devoid of the heme degradation activity. A 5-coor...

Journal: :Cardiovascular research 2002
Xiao-ming Liu Gary B Chapman Kelly J Peyton Andrew I Schafer William Durante

OBJECTIVE Carbon monoxide (CO) is generated from vascular smooth muscle cells via the degradation of heme by the enzyme heme oxygenase-1. Since smooth muscle cell apoptosis is associated with numerous vascular disorders, we investigated whether CO regulates apoptosis in vascular smooth muscle. METHODS AND RESULTS Treatment of cultured rat aortic smooth muscle cells with a combination of cytok...

Journal: :American journal of respiratory and critical care medicine 2005
Danielle Morse Augustine M K Choi

As aspects of basic science come to play an increasingly prominent role in clinical medicine, heme oxygenase-1 is one of several molecules emerging as a central player in diseases of the lung and intensive care unit. Although the apparent raison d'être of this enzyme is to dispose of heme, its activity results in cytoprotection against oxidative injury and cellular stresses. As the lung interfa...

Background: Hemoglobin is a protein in red blood cells, and the role of that is to transport the oxygen and carbon dioxide in the blood. This protein has a heme group that is a prosthetic group. Hemoglobin is known as a potent inducer for heme oxygenase enzyme. Also the administration of CO releasing compounds (CORMs) can reduce the neuropathic pain. So this study is based on the assumption tha...

2010
Brian T. Pratt Thierry Roger Laura E. Nagy Palash Mandal Sanjoy Roychowdhury Pil-Hoon Park

2001
Juan Cornejo Samuel Beale

Enzymatic heme oxygenase activity has been partially purified from extracts of the unicellular red alga Cyanidium caldarium, and the macromolecular components have been separated into three protein fractions, referred to as Fractions I, 11, and 111, by serial column chromatography through DEAE-cellulose and Reactive Blue 2-Sepharose. Fraction I is retained by DEAE-cellulose at low salt concentr...

Journal: :Current pharmaceutical design 2008
N G Abraham P L Tsenovoy J McClung G S Drummond

Heme oxygenase-1 (HO-1) is central to the regulation of oxidative injury. The role of increased HO-1 expression and Heme oxygenase (HO) activity in mitigating the detrimental side effect of diabetes is examined. A review of the mechanism(s) of action is included. This may lead to the development of pharmacological and genetic approaches to mitigate the clinical complications associated with the...

Journal: :Chemical communications 2012
Takeshi Uchida Yukari Sekine Toshitaka Matsui Masao Ikeda-Saito Koichiro Ishimori

HutZ, one of the crucial proteins of the iron uptake system in Vibrio cholerae, was purified, which binds to heme at a stoichiometry of 1 : 1. In the presence of ascorbic acid, the HutZ-bound heme degrades via the same intermediates observed in heme oxygenase, suggesting that HutZ works as a heme degradation enzyme.

Journal: :Haematologica 2015
Anupama Narla Narla Mohandas

2012
Khalil Karimi Nalaayini Kandiah Jessie Chau John Bienenstock Paul Forsythe

We investigated the consequences of feeding with a Lactobacillus species on the immune environment in GALT, and the role of dendritic cells and heme oxygenase-1 in mediating these responses. Feeding with a specific strain of Lactobacillus rhamnosus induced a significant increase in CD4+CD25+Foxp3+ functional regulatory T cells in GALT. This increase was greatest in the mesenteric lymph nodes an...

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