نتایج جستجو برای: hemimelia
تعداد نتایج: 143 فیلتر نتایج به سال:
After two generations of backcrossing six different Y-consomic strains onto a C57BL/6J inbred mouse strain with a dominant hemimelia (Dh) mutation, a small percentage of Dh/+ males containing a Y chromosome from the AKR/J or RF/J strain showed hermaphrodism; they lacked the right testis and had an ovary and a uterus instead. Approximately 15% of Dh/+ females considered to be phenotypically norm...
Objectives: Meniscal ramp lesions describe a specific injury to the meniscocapsular junction at posterior horn of medial meniscus. The are strongly associated with anterior cruciate ligament (ACL) injuries and may affect biomechanical stability knee if left untreated. Despite increasing rates ACL reconstructions performed in adolescents each year, prevalence risk factors for this patient popula...
BACKGROUND Split-hand/foot malformation (SHFM)-also known as ectrodactyly-is a congenital disorder characterised by severe malformations of the distal limbs affecting the central rays of hands and/or feet. A distinct entity termed SHFLD presents with SHFM and long bone deficiency. Mouse models suggest that a defect of the central apical ectodermal ridge leads to the phenotype. Although six diff...
A 9-month-old 10 kg intact male crossbred dog was admitted to The Animal Medical Centre, Chonbuk National University with congenitally malformed right forelimb. Physical exanimation of the limb showed varus deviation of the forepaw and flexion contracture of the interphalangeal joints. The survey radiographs revealed complete absence of the radius, poor congruency of the humeroulnar joint and 9...
Epithelial-mesenchymal interactions are essential for both limb outgrowth and pattern formation in the limb. Molecules capable of communication between these two tissues are known and include the signaling molecules SHH and FGF4, FGF8 and FGF10. Evidence suggests that the pattern and maintenance of expression of these genes are dependent on a number of factors including regulatory loops between...
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