OBJECTIVES The goal of this study is to provide a better understanding of the role of the cortex in sleep's macro- and microstructure modulation. METHODS Sleep architecture and phasic events were investigated in 4 patients having undergone right functional or anatomical hemispherectomy and 8 control subjects. Between-groups differences were assessed using the Wilcoxon-Mann-Whitney test. RES...

Walking flexibility depends on use of feedback or reactive control to respond to unexpected changes in the environment, and the ability to adapt feedforward or predictive control for sustained alterations. Recent work has demonstrated that cerebellar damage impairs feedforward adaptation, but not feedback control, during human split-belt treadmill walking. In contrast, focal cerebral damage fro...

Why do modern humans have larger brains than earlier people such as Homo erectus? As large brains cause problems in childbirth, infancy and locomotion, the advantage they offer must be substantial. This advantage might be associated with increased IQ, but there is a problem: evidence from MRI volumetric surveys, microcephaly and hemispherectomy shows that there exist individuals with psychometr...

T the best of current knowledge, the first hemispherectomy (HSPY) was undertaken in 1923 by Dr. Walter Dandy.1 It was reported independently in 1928 by L̓ Hermitte.2 These initial HSPY operations were utilized as a surgical treatment of cerebral gliomas. The initial optimism of potentially curing malignant gliomas led others to use the procedure for these tumors.3-7 Other than perhaps a question...

Individuals who have undergone hemispherectomy for treatment of intractable epilepsy offer a rare and valuable opportunity to examine the ability of a single cortical hemisphere to control oculomotor performance. We used peripheral auditory events to trigger saccades, thereby circumventing dense postsurgical hemianopia. In an antisaccade task, patients generated numerous unintended short-latenc...