We present a method to extract the haemodynamic response function (HRF) from a functional magnetic resonance imaging (fMRI) time series. The method is based on Fourierwavelet regularised deconvolution (ForWaRD). The extraction algorithm is very general: it relies only on the assumptions of the general linear model (GLM) and the fact that signal and noise can be distinguished in the frequency an...

We previously identified a negative correlation between histamine release to histamine releasing factor/translationally controlled tumor protein (HRF/TCTP) and protein levels of the Src homology 2 domain-containing inositol 5' phosphatase (SHIP) in basophils. We have also demonstrated that HRF/TCTP primes basophils to release mediators. The purpose of this study was to begin characterization of...

Histamine Releasing Factor (HRF) also known as Translationally Controlled Tumor Protein (TCTP) is a ubiquitous, novel protein that has both intracellular and extracellular functions. The purpose of this review is to highlight the background history of the molecule, the clinical implications and focus on the extracellular functions. Specifically the cells and the cytokines that are produced when...

PURPOSE To combine parallel imaging with 3D single-shot acquisition (echo volumar imaging, EVI) in order to acquire high temporal resolution volumar functional MRI (fMRI) data. MATERIALS AND METHODS An improved EVI sequence was associated with parallel acquisition and field of view reduction in order to acquire a large brain volume in 200 msec. Temporal stability and functional sensitivity we...

background : we aimed to compare hemodynamic and endocrine alterations caused by stress response due to proseal laryngeal mask airway and endotracheal tube usage in laparoscopic cholecystectomy. methods : sixty-three asa i-ii patients scheduled for elective laparoscopic cholecystectomy were included in the study. patients were randomly allocated into two groups of endotracheal tube and proseal ...

DNA double-strand breaks (DSBs) can be repaired via two main mechanisms: non-homologous end joining (NHEJ) and homologous recombination (HR). Our previous work showed that exposure to abiotic stresses resulted in an increase in point mutation frequency (PMF) and homologous recombination frequency (HRF), and these changes were heritable. We hypothesized that mutants impaired in DSB recognition a...

A fundamental question in neuroscience is how different brain areas communicate with each other. Dynamic causal modelling (DCM) is a generic formalism to study effective brain connectivity based on neuroimaging data, particularly functional magnetic resonance imaging (fMRI). The interactions between neuronal activity at different brain areas areas are modelled as a first-order differential equa...

background: etomidate and propofol are common anesthetic agents. previous studies say that etomidate can be used in patients with limited hemodynamic reserve and propofol can lead to more hemodynamic instabilities. th is study was performed to explore the cardiovascular response during the induction of anesthesia with etomidate or for comparison, propofol in elective orthopedic surgeries. mater...

background: although a variety of methods have been suggested to reduce stress, anxiety and pain intensity due to spinal needle skin puncture, their adverse effects restrict theirs widespread administration. in this study we evaluated the effects of oral tizanidine on the reduction of pain caused by spinal needle puncture and hemodynamic responses. methods : in this double blind randomized clin...

Introduction: The relationship between neuronal events and haemodynamic changes measured with blood-oxygenation-level-dependent (BOLD) functional MRI (fMRI) is still unknown, although many recent studies have provided a qualitative correspondence. The local neuromagnetic fields generated by the dendrites of cortical pyramidal cells can be measured non-invasively at the scalp with magnetoencepha...