Emerging evidence indicates that the aryl hydrocarbon receptor (AhR) plays a crucial role in normal physiologic homeostasis. Additionally, aberrant AhR signaling leads to several pathologic states in the lung and liver. Activation of AhR transcriptionally induces phase I (CYP1A) detoxifying enzymes. Although the effects of the classic AhR ligands such as 3-methylcholanthrene and dioxins on phas...

Dhahbi, Joseph M., Patricia L. Mote, John Wingo, John B. Tillman, Roy L. Walford, and Stephen R. Spindler. Calories and aging alter gene expression for gluconeogenic, glycolytic, and nitrogen-metabolizing enzymes. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E352–E360, 1999.—We characterized the effects of calorie restriction (CR) on the expression of key glycolytic, gluconeogenic, and nitrogen...

Phase II conjugating enzymes play key roles in the metabolism of xenobiotics. In the present study, RNA sequencing was used to elucidate hepatic ontogeny and tissue distribution of mRNA expression of all major known Phase II enzymes, including enzymes involved in glucuronidation, sulfation, glutathione conjugation, acetylation, methylation, and amino acid conjugation, as well as enzymes for the...

this study was designed to explore the protective effects of abrus precatorius l. (leguminosae) (ap) in hepg2 cells and n-nitrosodiethylamine (ndea) induced hepatocellular carcinoma in swiss albino rats. the effects of aqueous/ethanolic (50%) extract of ap on hepatic markers, haematological and histopathological parameters, and antioxidant enzymes were evaluated in ndea (200 mg/kg and ccl4, 3 m...

Urinary oxalate plays an important role in the formation of calcium oxalate stone, and endogenous oxalate metabolism mainly occurs in the liver. Since dehydroepiandrosterone (DHEA) is known to have an effect on hepatocellular proliferation and on some hepatic enzymes, we examined the influence of DHEA on the activity of hepatic oxalate-related enzymes and on urinary oxalate excretion in rats. F...

Aim: To evaluate the effects of green tea on liver enzymes of mice on high fat diet. Methods: Sixty adult mice, Balb-C strain were selected and divided into three groups. The control group was given standard laboratory diet throughout the study. In experimental group A, the study was carried out in two phases. In the first phase, hepatic steatosis was induced by high fat diet containing 4 perce...