نتایج جستجو برای: hepatic stellate cell
تعداد نتایج: 1763684 فیلتر نتایج به سال:
Irreversible hepatic fibrosis, an excessive production and accumulation of extra cellular matrix by stellate cells in the liver, becomes a remarkable economic burden global health care system.Low therapeutic efficacy undesirable systemic effect conventional therapies limit their clinical applications to targethepatic cells.
The p53 tumor suppressor can restrict malignant transformation by triggering cell-autonomous programs of cell-cycle arrest or apoptosis. p53 also promotes cellular senescence, a tumor-suppressive program that involves stable cell-cycle arrest and secretion of factors that modify the tissue microenvironment. In the presence of chronic liver damage, we show that ablation of a p53-dependent senesc...
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